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MGP000020

Record overview

MGPD IDMGP000020
Gene ID35
SpeciesHomo sapiens (Human)
Gene Nameacyl-CoA dehydrogenase, C-2 to C-3 short chain
Gene Symbol ACADS
SynonymsSCAD; ACAD3;
Alternate namesshort-chain specific acyl-CoA dehydrogenase, mitochondrial; acyl-Coenzyme A dehydrogenase, C-2 to C-3 short chain; butyryl-CoA dehydrogenase; mitochondrial short-chain specific acyl-CoA dehydrogenase; unsaturated acyl-CoA reductase;
Chromosome12
Map Location12q24.31
EC Number1.3.8.1
SummaryThis gene encodes a tetrameric mitochondrial flavoprotein, which is a member of the acyl-CoA dehydrogenase family. This enzyme catalyzes the initial step of the mitochondrial fatty acid beta-oxidation pathway. Mutations in this gene have been associated with short-chain acyl-CoA dehydrogenase (SCAD) deficiency. Alternative splicing results in two variants which encode different isoforms. [provided by RefSeq, Oct 2014]
OrthologsView orthologs and multiple alignments for ACADS

Proteins

short-chain specific acyl-CoA dehydrogenase, mitochondrial isoform 1 precursor
Refseq ID:NP_000008
Protein GI:4557233
UniProt ID:P16219
mRNA ID:NM_000017
Length:412
RefSeq Status:
MAAALLARASGPARRALCPRAWRQLHTIYQSVELPETHQMLLQTCRDFAEKELFPIAAQVDKEHLFPAAQVKKMGGLGLLAMDVPEELGGAGLDYLAYAI
AMEEISRGCASTGVIMSVNNSLYLGPILKFGSKEQKQAWVTPFTSGDKIGCFALSEPGNGSDAGAASTTARAEGDSWVLNGTKAWITNAWEASAAVVFAS
TDRALQNKGISAFLVPMPTPGLTLGKKEDKLGIRGSSTANLIFEDCRIPKDSILGEPGMGFKIAMQTLDMGRIGIASQALGIAQTALDCAVNYAENRMAF
GAPLTKLQVIQFKLADMALALESARLLTWRAAMLKDNKKPFIKEAAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERHYRDARITEIYEGTSEIQRL
VIAGHLLRSYRS
 
short-chain specific acyl-CoA dehydrogenase, mitochondrial isoform 2 precursor
Refseq ID:NP_001289483
Protein GI:700674279
UniProt ID:P16219
mRNA ID:NM_001302554
Length:408
RefSeq Status:
MAAALLARASGPARRALCPRAWRQLHTIYQSVELPETHQMLLQTCRDFAEKELFPIAAQVDKEHLFPAAQVKKMGGLGLLAMDVPEELGGAGLDYLAYAI
AMEEISRGCASTGVIMSVNNSLYLGPILKFGSKEQKQAWVTPFTSGDKIGCFALSEPGPSLLGPTGPIFALGQVGCPCPSSAATEACTFPRSRQRVSRPE
LLREGISAFLVPMPTPGLTLGKKEDKLGIRGSSTANLIFEDCRIPKDSILGEPGMGFKIAMQTLDMGRIGIASQALGIAQTALDCAVNYAENRMAFGAPL
TKLQVIQFKLADMALALESARLLTWRAAMLKDNKKPFIKEAAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERHYRDARITEIYEGTSEIQRLVIAG
HLLRSYRS
 
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