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MGP000029

UniProt Annotations

Entry Information
Gene Nameaconitase 1, soluble
Protein EntryACOC_HUMAN
UniProt IDP21399
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityCitrate = isocitrate.
CofactorName=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Evidence={ECO:0000269|PubMed:16407072}; Note=Binds 1 [4Fe-4S] cluster per subunit. {ECO:0000269|PubMed:16407072};
FunctionCatalyzes the isomerization of citrate to isocitrate via cis-aconitate. {ECO:0000250}.
FunctionIron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding. {ECO:0000269|PubMed:1946430, ECO:0000269|PubMed:8041788}.
InteractionP20929:NEB; NbExp=2; IntAct=EBI-2847111, EBI-1049657; Q13326:SGCG; NbExp=2; IntAct=EBI-2847111, EBI-5357343;
SimilarityBelongs to the aconitase/IPM isomerase family. {ECO:0000305}.
Subcellular LocationCytoplasm.
SubunitInteracts (when associated with the 4Fe-4S) with FBXL5. Interacts with frataxin(81-210). {ECO:0000269|PubMed:16407072, ECO:0000269|PubMed:19762596, ECO:0000269|PubMed:19762597, ECO:0000269|PubMed:20053667}.
Web ResourceName=Wikipedia; Note=Aconitase entry; URL="http://en.wikipedia.org/wiki/Aconitase";
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