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MGP000032

Record overview

MGPD IDMGP000032
Gene ID52
SpeciesHomo sapiens (Human)
Gene Nameacid phosphatase 1, soluble
Gene Symbol ACP1
SynonymsHAAP;
Alternate nameslow molecular weight phosphotyrosine protein phosphatase; LMW-PTP; LMW-PTPase; adipocyte acid phosphatase; red cell acid phosphatase 1; protein tyrosine phosphatase; acid phosphatase of erythrocyte; cytoplasmic phosphotyrosyl protein phosphatase; low molecular weight cytosolic acid phosphatase;
Chromosome2
Map Location2p25
EC Number3.1.3.48
SummaryThe product of this gene belongs to the phosphotyrosine protein phosphatase family of proteins. It functions as an acid phosphatase and a protein tyrosine phosphatase by hydrolyzing protein tyrosine phosphate to protein tyrosine and orthophosphate. This enzyme also hydrolyzes orthophosphoric monoesters to alcohol and orthophosphate. This gene is genetically polymorphic, and three common alleles segregating at the corresponding locus give rise to six phenotypes. Each allele appears to encode at least two electrophoretically different isozymes, Bf and Bs, which are produced in allele-specific ratios. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Aug 2008]
OrthologsView orthologs and multiple alignments for ACP1

Proteins

low molecular weight phosphotyrosine protein phosphatase isoform b
Refseq ID:NP_009030
Protein GI:6005988
UniProt ID:P24666
mRNA ID:NM_007099
Length:158
RefSeq Status:
MAEQATKSVLFVCLGNICRSPIAEAVFRKLVTDQNISENWVIDSGAVSDWNVGRSPDPRAVSCLRNHGIHTAHKARQITKEDFATFDYILCMDESNLRDL
NRKSNQVKTCKAKIELLGSYDPQKQLIIEDPYYGNDSDFETVYQQCVRCCRAFLEKAH
 
low molecular weight phosphotyrosine protein phosphatase isoform c
Refseq ID:NP_004291
Protein GI:4757714
UniProt ID:P24666
mRNA ID:NM_004300
Length:158
RefSeq Status:
MAEQATKSVLFVCLGNICRSPIAEAVFRKLVTDQNISENWRVDSAATSGYEIGNPPDYRGQSCMKRHGIPMSHVARQITKEDFATFDYILCMDESNLRDL
NRKSNQVKTCKAKIELLGSYDPQKQLIIEDPYYGNDSDFETVYQQCVRCCRAFLEKAH
 
low molecular weight phosphotyrosine protein phosphatase isoform d
Refseq ID:NP_001035739
Protein GI:96304457
UniProt ID:P24666
mRNA ID:NM_001040649
Length:112
RefSeq Status:
MAEQATKSVLFVCLGNICRSPIAEAVFRKLVTDQNISENWRVDSAATSGYEIGNPPDYRGQSCMKRHGIPMSHVARQVPSLDLKLCVLCFSGSLTAVLFL
TGTWAGPQTQEL
 
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