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MGP000035

Record overview

MGPD IDMGP000035
Gene ID59
SpeciesHomo sapiens (Human)
Gene Nameactin, alpha 2, smooth muscle, aorta
Gene Symbol ACTA2
SynonymsAAT6; ACTSA; MYMY5;
Alternate namesactin, aortic smooth muscle; alpha-cardiac actin; cell growth-inhibiting gene 46 protein;
Chromosome10
Map Location10q23.3
SummaryThe protein encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Defects in this gene cause aortic aneurysm familial thoracic type 6. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2008]
OrthologsView orthologs and multiple alignments for ACTA2

Proteins

actin, aortic smooth muscle
Refseq ID:NP_001135417
Protein GI:213688375
UniProt ID:P62736
mRNA ID:NM_001141945
Length:377
RefSeq Status:
MCEEEDSTALVCDNGSGLCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHSFYNELRVAP
EEHPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGY
SFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNV
LSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDEAGPSIVHRKCF
 
mat_peptide: 3..377
product: Actin, aortic smooth muscle
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P62736.1)
calculated_mol_wt: 41775
peptide sequence: 
EEEDSTALVCDNGSGLCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHSFYNELRVAPEE
HPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSF
VTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVLS
GGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDEAGPSIVHRKCF
 
actin, aortic smooth muscle
Refseq ID:NP_001604
Protein GI:4501883
UniProt ID:P62736
mRNA ID:NM_001613
Length:377
RefSeq Status:
Protein sequence is identical to GI:213688375 (mRNA isoform)
 
mat_peptide: 3..377
product: Actin, aortic smooth muscle
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P62736.1)
calculated_mol_wt: 41775
peptide sequence: 
EEEDSTALVCDNGSGLCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHSFYNELRVAPEE
HPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSF
VTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVLS
GGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDEAGPSIVHRKCF

mat_peptide: 3..377
product: Actin, aortic smooth muscle
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P62736.1)
calculated_mol_wt: 41775
peptide sequence: 
EEEDSTALVCDNGSGLCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHSFYNELRVAPEE
HPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSF
VTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVLS
GGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDEAGPSIVHRKCF
 
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