MGP Database

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MGP000043

Ontology/Pathway Information

Entrez Gene ID88
Gene Nameactinin, alpha 2
Gene Symbol ACTN2
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005884 TAS:ProtIncCactin filament
GO:0030864 IEA:EnsemblCcortical actin cytoskeleton
GO:0005856 NAS:UniProtKBCcytoskeleton
GO:0005829 TAS:ReactomeCcytosol
GO:0043197 TAS:UniProtKBCdendritic spine
GO:0005576 TAS:ReactomeCextracellular region
GO:0070062 IDA:UniProtKBCextracellular vesicular exosome
GO:0030175 IDA:UniProtKBCfilopodium
GO:0005925 IMP:UniProtKBCfocal adhesion
GO:0031093 TAS:ReactomeCplatelet alpha granule lumen
GO:0031143 TAS:UniProtKBCpseudopodium
GO:0030018 IDA:UniProtKBCZ disc
GO:0005509 IEA:InterProFcalcium ion binding
GO:0008092 IDA:UniProtKBFcytoskeletal protein binding
GO:0051373 IDA:UniProtKBFFATZ binding
GO:0042802 IPI:IntActFidentical protein binding
GO:0005178 TAS:UniProtKBFintegrin binding
GO:0044325 IPI:BHF-UCLFion channel binding
GO:0046983 IDA:UniProtKBFprotein dimerization activity
GO:0008307 TAS:ProtIncFstructural constituent of muscle
GO:0030375 IEA:EnsemblFthyroid hormone receptor coactivator activity
GO:0031432 IPI:BHF-UCLFtitin binding
GO:0070080 IPI:BHF-UCLFtitin Z domain binding
GO:0007596 TAS:ReactomePblood coagulation
GO:0007155 TAS:UniProtKBPcell adhesion
GO:0048041 IMP:UniProtKBPfocal adhesion assembly
GO:0030035 IDA:UniProtKBPmicrospike assembly
GO:0030049 TAS:ReactomePmuscle filament sliding
GO:1901017 IMP:BHF-UCLPnegative regulation of potassium ion transmembrane transporter activity
GO:0043267 IMP:BHF-UCLPnegative regulation of potassium ion transport
GO:2000009 IMP:BHF-UCLPnegative regulation of protein localization to cell surface
GO:0030168 TAS:ReactomePplatelet activation
GO:0002576 TAS:ReactomePplatelet degranulation
GO:1901018 IDA:BHF-UCLPpositive regulation of potassium ion transmembrane transporter activity
GO:0043268 IDA:BHF-UCLPpositive regulation of potassium ion transport
GO:0051289 IDA:UniProtKBPprotein homotetramerization
GO:0042981 NAS:UniProtKBPregulation of apoptotic process
GO:0042391 IMP:BHF-UCLPregulation of membrane potential
GO:0007268 TAS:ReactomePsynaptic transmission
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_20563Activation of NMDA receptor upon glutamate binding and postsynaptic events
REACT_111155Cell-Cell communication
REACT_20642CREB phosphorylation through the activation of CaMKII
REACT_20568CREB phosphorylation through the activation of Ras
REACT_604Hemostasis
REACT_17044Muscle contraction
REACT_23832Nephrin interactions
REACT_13685Neuronal System
REACT_15370Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
REACT_798Platelet activation, signaling and aggregation
REACT_318Platelet degranulation
REACT_20593Post NMDA receptor activation events
REACT_20546Ras activation uopn Ca2+ infux through NMDA receptor
REACT_1280Response to elevated platelet cytosolic Ca2+
REACT_16969Striated Muscle Contraction
REACT_13477Transmission across Chemical Synapses
REACT_20594Unblocking of NMDA receptor, glutamate binding and activation
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