MGP Database

MGP000050

Ontology/Pathway Information

Entrez Gene ID	100
Gene Name	adenosine deaminase
Gene Symbol	ADA
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0030054	IEA:UniProtKB-SubCell	C	cell junction
GO:0009986	IDA:UniProtKB	C	cell surface
GO:0005737	IDA:HPA	C	cytoplasm
GO:0060205	IEA:UniProtKB-SubCell	C	cytoplasmic membrane-bounded vesicle lumen
GO:0005829	TAS:Reactome	C	cytosol
GO:0032839	IEA:Ensembl	C	dendrite cytoplasm
GO:0009897	IDA:UniProtKB	C	external side of plasma membrane
GO:0005615	IEA:Ensembl	C	extracellular space
GO:0005764	IDA:UniProtKB	C	lysosome
GO:0016020	IDA:UniProtKB	C	membrane
GO:0043025	IEA:Ensembl	C	neuronal cell body
GO:0005886	IDA:HPA	C	plasma membrane
GO:0004000	IDA:UniProtKB	F	adenosine deaminase activity
GO:0001883	IEA:Ensembl	F	purine nucleoside binding
GO:0008270	IMP:UniProtKB	F	zinc ion binding
GO:0006154	IDA:UniProtKB	P	adenosine catabolic process
GO:0007568	IEA:Ensembl	P	aging
GO:0007155	IEA:UniProtKB-KW	P	cell adhesion
GO:0046061	IEA:Ensembl	P	dATP catabolic process
GO:0006157	IEA:Ensembl	P	deoxyadenosine catabolic process
GO:0048566	IEA:Ensembl	P	embryonic digestive tract development
GO:0002314	IEA:Ensembl	P	germinal center B cell differentiation
GO:0001821	IEA:Ensembl	P	histamine secretion
GO:0043103	IBA:RefGenome	P	hypoxanthine salvage
GO:0046103	ISS:UniProtKB	P	inosine biosynthetic process
GO:0001889	IEA:Ensembl	P	liver development
GO:0048286	IEA:Ensembl	P	lung alveolus development
GO:0060169	IDA:UniProtKB	P	negative regulation of adenosine receptor signaling pathway
GO:0042323	IEA:Ensembl	P	negative regulation of circadian sleep/wake cycle, non-REM sleep
GO:0050728	IEA:Ensembl	P	negative regulation of inflammatory response
GO:0002686	IEA:Ensembl	P	negative regulation of leukocyte migration
GO:0002906	IEA:Ensembl	P	negative regulation of mature B cell apoptotic process
GO:0070256	IEA:Ensembl	P	negative regulation of mucus secretion
GO:0060407	IEA:Ensembl	P	negative regulation of penile erection
GO:0070244	IEA:Ensembl	P	negative regulation of thymocyte apoptotic process
GO:0055086	TAS:Reactome	P	nucleobase-containing small molecule metabolic process
GO:0048541	IEA:Ensembl	P	Peyer's patch development
GO:0001890	IEA:Ensembl	P	placenta development
GO:0046638	IEA:Ensembl	P	positive regulation of alpha-beta T cell differentiation
GO:0030890	IEA:Ensembl	P	positive regulation of B cell proliferation
GO:0050850	IEA:Ensembl	P	positive regulation of calcium-mediated signaling
GO:0002636	IEA:Ensembl	P	positive regulation of germinal center formation
GO:0010460	IEA:Ensembl	P	positive regulation of heart rate
GO:0045987	IEA:Ensembl	P	positive regulation of smooth muscle contraction
GO:0033089	IEA:Ensembl	P	positive regulation of T cell differentiation in thymus
GO:0050862	IEA:Ensembl	P	positive regulation of T cell receptor signaling pathway
GO:0043101	TAS:Reactome	P	purine-containing compound salvage
GO:0006144	TAS:Reactome	P	purine nucleobase metabolic process
GO:0032261	IMP:UniProtKB	P	purine nucleotide salvage
GO:0009168	IEA:InterPro	P	purine ribonucleoside monophosphate biosynthetic process
GO:0033632	IDA:UniProtKB	P	regulation of cell-cell adhesion mediated by integrin
GO:0042493	IEA:Ensembl	P	response to drug
GO:0042542	IEA:Ensembl	P	response to hydrogen peroxide
GO:0001666	IDA:UniProtKB	P	response to hypoxia
GO:0043278	IEA:Ensembl	P	response to morphine
GO:0033197	IEA:Ensembl	P	response to vitamin E
GO:0044281	TAS:Reactome	P	small molecule metabolic process
GO:0042110	IDA:UniProtKB	P	T cell activation
GO:0001829	IEA:Ensembl	P	trophectodermal cell differentiation
GO:0046111	IEA:Ensembl	P	xanthine biosynthetic process

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_111217	Metabolism
REACT_1698	Metabolism of nucleotides
REACT_522	Purine metabolism
REACT_1923	Purine salvage

SMP Pathway Links

SMP ID	Description
SMP00535	Adenine phosphoribosyltransferase deficiency (APRT)
SMP00144	Adenosine Deaminase Deficiency
SMP00167	Adenylosuccinate Lyase Deficiency
SMP00168	AICA-Ribosiduria
SMP00427	Azathioprine Action Pathway
SMP00365	Gout or Kelley-Seegmiller Syndrome
SMP00364	Lesch-Nyhan Syndrome (LNS)
SMP00428	Mercaptopurine Action Pathway
SMP00536	Mitochondrial DNA depletion syndrome
SMP00203	Molybdenum Cofactor Deficiency
SMP00537	Myoadenylate deaminase deficiency
SMP00050	Purine Metabolism
SMP00210	Purine Nucleoside Phosphorylase Deficiency
SMP00430	Thioguanine Action Pathway
SMP00220	Xanthine Dehydrogenase Deficiency (Xanthinuria)
SMP00512	Xanthinuria type I
SMP00513	Xanthinuria type II