MGP Database

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MGP000052

Ontology/Pathway Information

Entrez Gene ID102
Gene NameADAM metallopeptidase domain 10
Gene Symbol ADAM10
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0009986 IDA:UniProtKBCcell surface
GO:0005737 ISS:UniProtKBCcytoplasm
GO:0070062 IDA:UniProtKBCextracellular vesicular exosome
GO:0005925 IDA:UniProtKBCfocal adhesion
GO:0005794 IDA:UniProtKBCGolgi apparatus
GO:0005798 IDA:UniProtKBCGolgi-associated vesicle
GO:0016021 NAS:UniProtKBCintegral component of membrane
GO:0016020 IDA:UniProtKBCmembrane
GO:0005634 ISS:UniProtKBCnucleus
GO:0097038 IDA:UniProtKBCperinuclear endoplasmic reticulum
GO:0005886 TAS:ReactomeCplasma membrane
GO:0014069 IEA:EnsemblCpostsynaptic density
GO:0097197 IDA:UniProtKBCtetraspanin-enriched microdomain
GO:0004175 ISS:UniProtKBFendopeptidase activity
GO:0005178 NAS:UniProtKBFintegrin binding
GO:0004222 IMP:UniProtKBFmetalloendopeptidase activity
GO:0008237 IDA:UniProtKBFmetallopeptidase activity
GO:0042803 ISS:UniProtKBFprotein homodimerization activity
GO:0019901 ISS:UniProtKBFprotein kinase binding
GO:0005102 NAS:UniProtKBFreceptor binding
GO:0008270 IEA:InterProFzinc ion binding
GO:0007267 NAS:UniProtKBPcell-cell signaling
GO:0030574 TAS:ReactomePcollagen catabolic process
GO:0051089 IDA:UniProtKBPconstitutive protein ectodomain proteolysis
GO:0007173 TAS:ReactomePepidermal growth factor receptor signaling pathway
GO:0022617 TAS:ReactomePextracellular matrix disassembly
GO:0030198 TAS:ReactomePextracellular matrix organization
GO:0007229 NAS:UniProtKBPintegrin-mediated signaling pathway
GO:0001701 ISS:UniProtKBPin utero embryonic development
GO:0006509 IDA:UniProtKBPmembrane protein ectodomain proteolysis
GO:0042117 IMP:BHF-UCLPmonocyte activation
GO:0007162 IDA:UniProtKBPnegative regulation of cell adhesion
GO:0007220 TAS:ReactomePNotch receptor processing
GO:0007219 ISS:UniProtKBPNotch signaling pathway
GO:0051088 IMP:BHF-UCLPPMA-inducible membrane protein ectodomain proteolysis
GO:0030307 IMP:BHF-UCLPpositive regulation of cell growth
GO:0030335 IMP:BHF-UCLPpositive regulation of cell migration
GO:0008284 IMP:BHF-UCLPpositive regulation of cell proliferation
GO:0010820 IMP:BHF-UCLPpositive regulation of T cell chemotaxis
GO:0006468 ISS:UniProtKBPprotein phosphorylation
GO:0034612 IDA:BHF-UCLPresponse to tumor necrosis factor
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_118614Activated NOTCH1 Transmits Signal to the Nucleus
REACT_18266Axon guidance
REACT_150401Collagen degradation
REACT_160089Constitutive Signaling by NOTCH1 HD Domain Mutants
REACT_160254Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
REACT_160243Constitutive Signaling by NOTCH1 PEST Domain Mutants
REACT_160106Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
REACT_118572Degradation of the extracellular matrix
REACT_111045Developmental Biology
REACT_116125Disease
REACT_264198EPH-ephrin mediated repulsion of cells
REACT_264068EPH-Ephrin signaling
REACT_118779Extracellular matrix organization
REACT_160099FBXW7 Mutants and NOTCH1 in Cancer
REACT_160205NOTCH2 Activation and Transmission of Signal to the Nucleus
REACT_9417Signaling by EGFR
REACT_115871Signaling by EGFR in Cancer
REACT_268269Signaling by EGFRvIII in Cancer
REACT_268006Signaling by Ligand-Responsive EGFR Variants in Cancer
REACT_299Signaling by NOTCH
REACT_118859Signaling by NOTCH1
REACT_160133Signaling by NOTCH1 HD Domain Mutants in Cancer
REACT_160248Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
REACT_160214Signaling by NOTCH1 in Cancer
REACT_160301Signaling by NOTCH1 PEST Domain Mutants in Cancer
REACT_160082Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
REACT_118721Signaling by NOTCH2
REACT_118862Signaling by NOTCH3
REACT_118636Signaling by NOTCH4
REACT_268546Signaling by Overexpressed Wild-Type EGFR in Cancer
REACT_111102Signal Transduction
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