MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP000059

UniProt Annotations

Entry Information
Gene Nameadenylate cyclase 6
Protein EntryADCY6_HUMAN
UniProt IDO43306
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=O43306-1; Sequence=Displayed; Name=2; IsoId=O43306-2; Sequence=VSP_000244; Note=No experimental confirmation available.;
Catalytic ActivityATP = 3',5'-cyclic AMP + diphosphate.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250}; Note=Binds 2 magnesium ions per subunit. {ECO:0000250};
Enzyme RegulationInhibition by calcium in the submicromolar concentration range (By similarity). Phosphorylation by RAF1 results in its activation. {ECO:0000250, ECO:0000269|PubMed:15385642}.
FunctionMembrane-bound, calcium-inhibitable adenylyl cyclase. {ECO:0000250}.
PtmPhosphorylated by RAF1. {ECO:0000269|PubMed:15385642, ECO:0000269|PubMed:18088087}.
Sequence CautionSequence=BAA24852.2; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the adenylyl cyclase class-4/guanylyl cyclase family. {ECO:0000255|PROSITE-ProRule:PRU00099}.
SimilarityContains 2 guanylate cyclase domains. {ECO:0000255|PROSITE-ProRule:PRU00099}.
Subcellular LocationMembrane; Multi-pass membrane protein. Cell projection, cilium {ECO:0000250}.
SubunitPart of a complex containing AKAP5, ADCY5, PDE4C and PKD2 (By similarity). Interacts with RAF1. {ECO:0000250, ECO:0000269|PubMed:15385642}.
  logo