MGP Database

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MGP000062

UniProt Annotations

Entry Information
Gene Nameadenylate cyclase 9
Protein EntryADCY9_HUMAN
UniProt IDO60503
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityATP = 3',5'-cyclic AMP + diphosphate.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Binds 2 magnesium ions per subunit.;
Enzyme RegulationInsensitive to calcium/calmodulin, forskolin and somatostatin. Stimulated by beta-adrenergic receptor activation.
FunctionMay play a fundamental role in situations where fine interplay between intracellular calcium and cAMP determines the cellular function. May be a physiologically relevant docking site for calcineurin (By similarity). {ECO:0000250}.
Sequence CautionSequence=AAC24201.1; Type=Frameshift; Positions=1252; Evidence={ECO:0000305}; Sequence=BAA25446.3; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
SimilarityBelongs to the adenylyl cyclase class-4/guanylyl cyclase family. {ECO:0000255|PROSITE-ProRule:PRU00099}.
SimilarityContains 2 guanylate cyclase domains. {ECO:0000255|PROSITE-ProRule:PRU00099}.
Subcellular LocationMembrane; Multi-pass membrane protein.
Tissue SpecificityExpressed in multiple cells of the lung, with expression highest in airway smooth muscle. {ECO:0000269|PubMed:12972952}.
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