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MGP000069

Record overview

MGPD IDMGP000069
Gene ID127
SpeciesHomo sapiens (Human)
Gene Namealcohol dehydrogenase 4 (class II), pi polypeptide
Gene Symbol ADH4
SynonymsADH-2; HEL-S-4;
Alternate namesalcohol dehydrogenase 4; alcohol dehydrogenase class II pi chain; aldehyde reductase; epididymis secretory protein Li 4;
Chromosome4
Map Location4q22
EC Number1.1.1.1
SummaryThis gene encodes class II alcohol dehydrogenase 4 pi subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class II alcohol dehydrogenase is a homodimer composed of 2 pi subunits. It exhibits a high activity for oxidation of long-chain aliphatic alcohols and aromatic alcohols and is less sensitive to pyrazole. This gene is localized to chromosome 4 in the cluster of alcohol dehydrogenase genes. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for ADH4

Proteins

alcohol dehydrogenase 4
Refseq ID:NP_000661
Protein GI:71565152
UniProt ID:P08319
mRNA ID:NM_000670
Length:380
RefSeq Status:
MGTKGKVIKCKAAIAWEAGKPLCIEEVEVAPPKAHEVRIQIIATSLCHTDATVIDSKFEGLAFPVIVGHEAAGIVESIGPGVTNVKPGDKVIPLYAPLCR
KCKFCLSPLTNLCGKISNLKSPASDQQLMEDKTSRFTCKGKPVYHFFGTSTFSQYTVVSDINLAKIDDDANLERVCLLGCGFSTGYGAAINNAKVTPGST
CAVFGLGGVGLSAVMGCKAAGASRIIGIDINSEKFVKAKALGATDCLNPRDLHKPIQEVIIELTKGGVDFALDCAGGSETMKAALDCTTAGWGSCTFIGV
AAGSKGLTIFPEELIIGRTINGTFFGGWKSVDSIPKLVTDYKNKKFNLDALVTHTLPFDKISEAFDLMNQGKSVRTILIF
 
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