MGP Database

MGP000086

Ontology/Pathway Information

Entrez Gene ID	154
Gene Name	adrenoceptor beta 2, surface
Gene Symbol	ADRB2
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0016324	IEA:Ensembl	C	apical plasma membrane
GO:0005768	TAS:ProtInc	C	endosome
GO:0005887	IDA:BHF-UCL	C	integral component of plasma membrane
GO:0005764	TAS:ProtInc	C	lysosome
GO:0005634	IEA:Ensembl	C	nucleus
GO:0005886	IDA:MGI	C	plasma membrane
GO:0043235	IDA:HGNC	C	receptor complex
GO:0004941	IDA:HGNC	F	beta2-adrenergic receptor activity
GO:0051380	IDA:HGNC	F	norepinephrine binding
GO:0015459	IDA:BHF-UCL	F	potassium channel regulator activity
GO:0042803	IDA:HGNC	F	protein homodimerization activity
GO:0007190	IDA:HGNC	P	activation of adenylate cyclase activity
GO:0007171	TAS:ProtInc	P	activation of transmembrane receptor protein tyrosine kinase activity
GO:0007189	IEA:Ensembl	P	adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007188	TAS:ProtInc	P	adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0071875	IDA:GOC	P	adrenergic receptor signaling pathway
GO:0045453	IEA:Ensembl	P	bone resorption
GO:0050873	IEA:Ensembl	P	brown fat cell differentiation
GO:0007166	TAS:ProtInc	P	cell surface receptor signaling pathway
GO:0002032	IDA:HGNC	P	desensitization of G-protein coupled receptor protein signaling pathway by arrestin
GO:0002024	IEA:Ensembl	P	diet induced thermogenesis
GO:0008333	TAS:ProtInc	P	endosome to lysosome transport
GO:0031649	IEA:Ensembl	P	heat generation
GO:0040015	IEA:Ensembl	P	negative regulation of multicellular organism growth
GO:0045986	IEA:Ensembl	P	negative regulation of smooth muscle contraction
GO:0030501	IEA:Ensembl	P	positive regulation of bone mineralization
GO:0043410	IDA:HGNC	P	positive regulation of MAPK cascade
GO:0031398	IMP:BHF-UCL	P	positive regulation of protein ubiquitination
GO:0045944	IEA:Ensembl	P	positive regulation of transcription from RNA polymerase II promoter
GO:0006898	IDA:HGNC	P	receptor-mediated endocytosis
GO:0002028	IEA:Ensembl	P	regulation of sodium ion transport
GO:0042312	IEA:InterPro	P	regulation of vasodilation
GO:0009409	IEA:Ensembl	P	response to cold
GO:0002025	IEA:Ensembl	P	vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_16927	Adrenoceptors
REACT_16983	Amine ligand-binding receptors
REACT_14828	Class A/1 (Rhodopsin-like receptors)
REACT_267874	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
REACT_116125	Disease
REACT_19327	G alpha (s) signalling events
REACT_19184	GPCR downstream signaling
REACT_21340	GPCR ligand binding
REACT_267615	Metabolic disorders of biological oxidation enzymes
REACT_14797	Signaling by GPCR
REACT_111102	Signal Transduction