MGP Database

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MGP000089

Ontology/Pathway Information

Entrez Gene ID158
Gene Nameadenylosuccinate lyase
Gene Symbol ADSL
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005829 TAS:ReactomeCcytosol
GO:0004018 IDA:UniProtKBFN6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity
GO:0070626 IEA:UniProtKB-ECF(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity
GO:0006167 IDA:UniProtKBPAMP biosynthetic process
GO:0044208 IEA:UniProtKB-UniPathwayP'de novo' AMP biosynthetic process
GO:0006189 IEA:UniProtKB-UniPathwayP'de novo' IMP biosynthetic process
GO:0008152 IDA:GOCPmetabolic process
GO:0055086 TAS:ReactomePnucleobase-containing small molecule metabolic process
GO:0051262 IDA:UniProtKBPprotein tetramerization
GO:0006144 TAS:ReactomePpurine nucleobase metabolic process
GO:0006164 IC:UniProtKBPpurine nucleotide biosynthetic process
GO:0009168 TAS:ReactomePpurine ribonucleoside monophosphate biosynthetic process
GO:0044281 TAS:ReactomePsmall molecule metabolic process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_111217Metabolism
REACT_1698Metabolism of nucleotides
REACT_522Purine metabolism
REACT_1776Purine ribonucleoside monophosphate biosynthesis
SMP Pathway Links
SMP IDDescription
SMP00535Adenine phosphoribosyltransferase deficiency (APRT)
SMP00144Adenosine Deaminase Deficiency
SMP00167Adenylosuccinate Lyase Deficiency
SMP00168AICA-Ribosiduria
SMP00067Aspartate Metabolism
SMP00427Azathioprine Action Pathway
SMP00175Canavan Disease
SMP00365Gout or Kelley-Seegmiller Syndrome
SMP00192Hypoacetylaspartia
SMP00364Lesch-Nyhan Syndrome (LNS)
SMP00428Mercaptopurine Action Pathway
SMP00536Mitochondrial DNA depletion syndrome
SMP00203Molybdenum Cofactor Deficiency
SMP00537Myoadenylate deaminase deficiency
SMP00050Purine Metabolism
SMP00210Purine Nucleoside Phosphorylase Deficiency
SMP00430Thioguanine Action Pathway
SMP00220Xanthine Dehydrogenase Deficiency (Xanthinuria)
SMP00512Xanthinuria type I
SMP00513Xanthinuria type II
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