MGP Database

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MGP000105

Ontology/Pathway Information

Entrez Gene ID191
Gene Nameadenosylhomocysteinase
Gene Symbol AHCY
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 IDA:HPACcytoplasm
GO:0005829 TAS:ReactomeCcytosol
GO:0070062 IDA:UniProtKBCextracellular vesicular exosome
GO:0042470 IEA:UniProtKB-SubCellCmelanosome
GO:0004013 TAS:UniProtKBFadenosylhomocysteinase activity
GO:0034641 TAS:ReactomePcellular nitrogen compound metabolic process
GO:0032259 TAS:ReactomePmethylation
GO:0006730 IEA:UniProtKB-KWPone-carbon metabolic process
GO:0044281 TAS:ReactomePsmall molecule metabolic process
GO:0000096 TAS:ReactomePsulfur amino acid metabolic process
GO:0006805 TAS:ReactomePxenobiotic metabolic process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_13433Biological oxidations
REACT_268587Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD)
REACT_268321Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD)
REACT_268129Defective GGT1 causes Glutathionuria (GLUTH)
REACT_267887Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)
REACT_268063Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD)
REACT_268256Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD)
REACT_267818Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD)
REACT_268027Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency)
REACT_268058Defective UGT1A1 causes hyperbilirubinemia
REACT_268618Defective UGT1A4 causes hyperbilirubinemia
REACT_116125Disease
REACT_267615Metabolic disorders of biological oxidation enzymes
REACT_111217Metabolism
REACT_13Metabolism of amino acids and derivatives
REACT_6946Methylation
REACT_6959Phase II conjugation
REACT_115639Sulfur amino acid metabolism
SMP Pathway Links
SMP IDDescription
SMP00123Betaine Metabolism
SMP00177Cystathionine Beta-Synthase Deficiency
SMP00222Glycine N-methyltransferase Deficiency
SMP00570Homocystinuria-megaloblastic anemia due to defect in cobalamin metabolism, cblG complementation type
SMP00341Hypermethioninemia
SMP00221Methionine Adenosyltransferase Deficiency
SMP00033Methionine Metabolism
SMP00340Methylenetetrahydrofolate Reductase Deficiency (MTHFRD)
SMP00214S-Adenosylhomocysteine (SAH) Hydrolase Deficiency
SMP00029Selenoamino Acid Metabolism
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