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MGP000110

Record overview

MGPD IDMGP000110
Gene ID210
SpeciesHomo sapiens (Human)
Gene Nameaminolevulinate dehydratase
Gene Symbol ALAD
SynonymsPBGS; ALADH;
Alternate namesdelta-aminolevulinic acid dehydratase; porphobilinogen synthase; aminolevulinate, delta-, dehydratase;
Chromosome9
Map Location9q33.1
EC Number4.2.1.24
SummaryThe ALAD enzyme is composed of 8 identical subunits and catalyzes the condensation of 2 molecules of delta-aminolevulinate to form porphobilinogen (a precursor of heme, cytochromes and other hemoproteins). ALAD catalyzes the second step in the porphyrin and heme biosynthetic pathway; zinc is essential for enzymatic activity. ALAD enzymatic activity is inhibited by lead and a defect in the ALAD structural gene can cause increased sensitivity to lead poisoning and acute hepatic porphyria. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for ALAD

Proteins

delta-aminolevulinic acid dehydratase
Refseq ID:NP_000022
Protein GI:189083849
UniProt ID:P13716
mRNA ID:NM_000031
Length:330
RefSeq Status:
MQPQSVLHSGYFHPLLRAWQTATTTLNASNLIYPIFVTDVPDDIQPITSLPGVARYGVKRLEEMLRPLVEEGLRCVLIFGVPSRVPKDERGSAADSEESP
AIEAIHLLRKTFPNLLVACDVCLCPYTSHGHCGLLSENGAFRAEESRQRLAEVALAYAKAGCQVVAPSDMMDGRVEAIKEALMAHGLGNRVSVMSYSAKF
ASCFYGPFRDAAKSSPAFGDRRCYQLPPGARGLALRAVDRDVREGADMLMVKPGMPYLDIVREVKDKHPDLPLAVYHVSGEFAMLWHGAQAGAFDLKAAV
LEAMTAFRRAGADIIITYYTPQLLQWLKEE
 
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