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MGP000113

UniProt Annotations

Entry Information
Gene Namealbumin
Protein EntryALBU_HUMAN
UniProt IDP02768
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=P02768-1; Sequence=Displayed; Name=2; IsoId=P02768-2; Sequence=VSP_021275; Name=3; IsoId=P02768-3; Sequence=VSP_057389; Note=No experimental confirmation available.;
CautionA peptide arising from positions 166 to 174 was originally (PubMed:3087352 and PubMed:2437111) termed neurotensin- related peptide (NRP) or kinetensin and was thought to regulate fat digestion, lipid absorption, and blood flow. {ECO:0000305}.
DiseaseHyperthyroxinemia, familial dysalbuminemic (FDAH) [MIM:615999]: A disorder characterized by abnormally elevated levels of total serum thyroxine (T4) in euthyroid patients. It is due to abnormal serum albumin that binds T4 with enhanced affinity. {ECO:0000269|PubMed:7852505, ECO:0000269|PubMed:8048949, ECO:0000269|PubMed:9329347, ECO:0000269|PubMed:9589637}. Note=The disease is caused by mutations affecting the gene represented in this entry.
FunctionSerum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc. {ECO:0000269|PubMed:19021548}.
InteractionP02786:TFRC; NbExp=2; IntAct=EBI-714423, EBI-355727;
PolymorphismA variant structure of albumin could lead to increased binding of zinc resulting in an asymptomatic augmentation of zinc concentration in the blood. The sequence shown is that of variant albumin A.
PtmAcetylated on Lys-223 by acetylsalicylic acid.
PtmGlycated in diabetic patients.
PtmKenitra variant is partially O-glycosylated at Thr-620. It has two new disulfide bonds Cys-600 to Cys-602 and Cys-601 to Cys- 606.
PtmPhosphorylation sites are present in the extracellular medium. {ECO:0000269|PubMed:18318008, ECO:0000269|PubMed:19690332}.
Sequence CautionSequence=AAF22034.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAF69644.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAG35503.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
SimilarityBelongs to the ALB/AFP/VDB family. {ECO:0000255|PROSITE-ProRule:PRU00769}.
SimilarityContains 3 albumin domains. {ECO:0000255|PROSITE- ProRule:PRU00769}.
Subcellular LocationSecreted.
Tissue SpecificityPlasma.
Web ResourceName=Albumin Website; URL="http://www.albumin.org";
Web ResourceName=SeattleSNPs; URL="http://pga.gs.washington.edu/data/alb/";
Web ResourceName=Wikipedia; Note=Serum albumin entry; URL="http://en.wikipedia.org/wiki/Serum_albumin";
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