MGP Database

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MGP000114

UniProt Annotations

Entry Information
Gene Nameactivated leukocyte cell adhesion molecule
Protein EntryCD166_HUMAN
UniProt IDQ13740
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q13740-1; Sequence=Displayed; Name=2; IsoId=Q13740-2; Sequence=VSP_021797; Name=3; Synonyms=sALCAM; IsoId=Q13740-3; Sequence=VSP_053530, VSP_053531; Note=Secreted form, inhibits isoform 1 homophilic interaction.; Name=4; IsoId=Q13740-4; Sequence=VSP_053529, VSP_053532; Note=No experimental confirmation available.;
DomainThe CD6 binding site is located in the N-terminal Ig-like domain. {ECO:0000269|PubMed:8823162}.
FunctionCell adhesion molecule that binds to CD6. Involved in neurite extension by neurons via heterophilic and homophilic interactions. May play a role in the binding of T- and B-cells to activated leukocytes, as well as in interactions between cells of the nervous system.
InteractionP30203:CD6; NbExp=2; IntAct=EBI-1188108, EBI-2873748; P09382:LGALS1; NbExp=3; IntAct=EBI-1188108, EBI-1048875; P17931:LGALS3; NbExp=3; IntAct=EBI-1188108, EBI-1170392;
SimilarityContains 2 Ig-like V-type (immunoglobulin-like) domains. {ECO:0000305}.
SimilarityContains 3 Ig-like C2-type (immunoglobulin-like) domains. {ECO:0000305}.
Subcellular LocationIsoform 3: Secreted {ECO:0000269|PubMed:15496415}.
Subcellular LocationMembrane; Single-pass type I membrane protein.
Tissue SpecificitySpleen, placenta, liver, and weakly in liver. Expressed by activated T-cells, B-cells, monocytes and thymic epithelial cells. Expressed by neurons in the brain. Restricted expression in tumor cell lines. Preferentially expressed in highly metastasizing melanoma cell lines. {ECO:0000269|PubMed:9502422}.
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