MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP000117

Ontology/Pathway Information

Entrez Gene ID217
Gene Namealdehyde dehydrogenase 2 family (mitochondrial)
Gene Symbol ALDH2
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0070062 IDA:UniProtKBCextracellular vesicular exosome
GO:0005759 TAS:ReactomeCmitochondrial matrix
GO:0004029 EXP:ReactomeFaldehyde dehydrogenase (NAD) activity
GO:0004030 TAS:ProtIncFaldehyde dehydrogenase [NAD(P)+] activity
GO:0009055 TAS:UniProtKBFelectron carrier activity
GO:0006066 TAS:ProtIncPalcohol metabolic process
GO:0005975 TAS:ProtIncPcarbohydrate metabolic process
GO:0006068 IEA:UniProtKB-UniPathwayPethanol catabolic process
GO:0006069 TAS:ReactomePethanol oxidation
GO:0042136 TAS:ReactomePneurotransmitter biosynthetic process
GO:0044281 TAS:ReactomePsmall molecule metabolic process
GO:0007268 TAS:ReactomePsynaptic transmission
GO:0006805 TAS:ReactomePxenobiotic metabolic process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_13433Biological oxidations
REACT_268767Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)
REACT_268601Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4)
REACT_268761Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency)
REACT_268217Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5)
REACT_268478Defective CYP19A1 causes Aromatase excess syndrome (AEXS)
REACT_268087Defective CYP1B1 causes Glaucoma
REACT_267893Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)
REACT_268803Defective CYP24A1 causes Hypercalcemia, infantile (HCAI)
REACT_268108Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA)
REACT_267734Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4)
REACT_268413Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX)
REACT_268633Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A)
REACT_268491Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B)
REACT_268326Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56)
REACT_268441Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5)
REACT_267709Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3)
REACT_268486Defective FMO3 causes Trimethylaminuria (TMAU)
REACT_267863Defective MAOA causes Brunner syndrome (BRUNS)
REACT_268528Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD)
REACT_116125Disease
REACT_34Ethanol oxidation
REACT_267615Metabolic disorders of biological oxidation enzymes
REACT_111217Metabolism
REACT_15532Metabolism of serotonin
REACT_13685Neuronal System
REACT_13583Neurotransmitter Clearance In The Synaptic Cleft
REACT_13705Phase 1 - Functionalization of compounds
REACT_15391Serotonin clearance from the synaptic cleft
REACT_13477Transmission across Chemical Synapses
SMP Pathway Links
SMP IDDescription
SMP001372-Methyl-3-Hydroxybutryl CoA Dehydrogenase Deficiency
SMP001383-Hydroxy-3-Methylglutaryl-CoA Lyase Deficiency
SMP005213-hydroxyisobutyric acid dehydrogenase deficiency
SMP005223-hydroxyisobutyric aciduria
SMP002373-Methylcrotonyl Coa Carboxylase Deficiency Type I
SMP001393-Methylglutaconic Aciduria Type I
SMP001403-Methylglutaconic Aciduria Type III
SMP001413-Methylglutaconic Aciduria Type IV
SMP007213-Phosphoglycerate dehydrogenase deficiency
SMP00007Beta-Alanine Metabolism
SMP00173Beta-Ketothiolase Deficiency
SMP00493Carnosinuria, carnosinemia
SMP00179Dihydropyrimidine Dehydrogenase Deficiency (DHPD)
SMP00242Dimethylglycine Dehydrogenase Deficiency
SMP00484Dimethylglycinuria
SMP00429Disulfiram Action Pathway
SMP00449Ethanol Degradation
SMP00351GABA-Transaminase Deficiency
SMP00004Glycine and Serine Metabolism
SMP00044Histidine Metabolism
SMP00191Histidinemia
SMP00485Hyperglycinemia, non-ketotic
SMP00523Isobutyryl-coa dehydrogenase deficiency
SMP00524Isovaleric acidemia
SMP00238Isovaleric Aciduria
SMP00196Leigh Syndrome
SMP00199Maple Syrup Urine Disease
SMP00384Methylmalonate Semialdehyde Dehydrogenase Deficiency
SMP00200Methylmalonic Aciduria
SMP00223Non Ketotic Hyperglycinemia
SMP00030Oxidation of Branched Chain Fatty Acids
SMP00558Primary hyperoxaluria II, PH2
SMP00236Propionic Acidemia
SMP00334Pyruvate Decarboxylase E1 Component Deficiency (PDHE1 Deficiency)
SMP00212Pyruvate Dehydrogenase Complex Deficiency
SMP00559Pyruvate kinase deficiency
SMP00060Pyruvate Metabolism
SMP00244Sarcosinemia
SMP00063Tryptophan Metabolism
SMP00492Ureidopropionase deficiency
SMP00032Valine, Leucine and Isoleucine Degradation
  logo