MGP Database

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MGP000119

UniProt Annotations

Entry Information
Gene Namealdehyde dehydrogenase 1 family, member B1
Protein EntryAL1B1_HUMAN
UniProt IDP30837
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityAn aldehyde + NAD(+) + H(2)O = a carboxylate + NADH.
FunctionALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation.
PathwayAlcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2.
SimilarityBelongs to the aldehyde dehydrogenase family. {ECO:0000305}.
Subcellular LocationMitochondrion matrix.
SubunitHomotetramer. {ECO:0000250}.
Tissue SpecificityLiver, testis and to a lesser extent in brain.
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