MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP000124

Record overview

MGPD IDMGP000124
Gene ID226
SpeciesHomo sapiens (Human)
Gene Namealdolase A, fructose-bisphosphate
Gene Symbol ALDOA
SynonymsALDA; GSD12; HEL-S-87p;
Alternate namesfructose-bisphosphate aldolase A; muscle-type aldolase; lung cancer antigen NY-LU-1; fructose-1,6-bisphosphate triosephosphate-lyase; epididymis secretory sperm binding protein Li 87p;
Chromosome16
Map Location16p11.2
EC Number4.1.2.13
SummaryThe protein encoded by this gene, Aldolase A (fructose-bisphosphate aldolase), is a glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Three aldolase isozymes (A, B, and C), encoded by three different genes, are differentially expressed during development. Aldolase A is found in the developing embryo and is produced in even greater amounts in adult muscle. Aldolase A expression is repressed in adult liver, kidney and intestine and similar to aldolase C levels in brain and other nervous tissue. Aldolase A deficiency has been associated with myopathy and hemolytic anemia. Alternative splicing and alternative promoter usage results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 3 and 10. [provided by RefSeq, Aug 2011]
OrthologsView orthologs and multiple alignments for ALDOA

Proteins

fructose-bisphosphate aldolase A isoform 1
Refseq ID:NP_001121089
Protein GI:193794814
UniProt ID:P04075
mRNA ID:NM_001127617
Length:364
RefSeq Status:
MPYQYPALTPEQKKELSDIAHRIVAPGKGILAADESTGSIAKRLQSIGTENTEENRRFYRQLLLTADDRVNPCIGGVILFHETLYQKADDGRPFPQVIKS
KGGVVGIKVDKGVVPLAGTNGETTTQGLDGLSERCAQYKKDGADFAKWRCVLKIGEHTPSALAIMENANVLARYASICQQNGIVPIVEPEILPDGDHDLK
RCQYVTEKVLAAVYKALSDHHIYLEGTLLKPNMVTPGHACTQKFSHEEIAMATVTALRRTVPPAVTGITFLSGGQSEEEASINLNAINKCPLLKPWALTF
SYGRALQASALKAWGGKKENLKAAQEEYVKRALANSLACQGKYTPSGQAGAAASESLFVSNHAY
 
fructose-bisphosphate aldolase A isoform 1
Refseq ID:NP_908930
Protein GI:34577110
UniProt ID:P04075
mRNA ID:NM_184041
Length:364
RefSeq Status:
Protein sequence is identical to GI:193794814 (mRNA isoform)
 
fructose-bisphosphate aldolase A isoform 1
Refseq ID:NP_000025
Protein GI:4557305
UniProt ID:P04075
mRNA ID:NM_000034
Length:364
RefSeq Status:
Protein sequence is identical to GI:193794814 (mRNA isoform)
 
fructose-bisphosphate aldolase A isoform 1
Refseq ID:NP_908932
Protein GI:34577112
UniProt ID:P04075
mRNA ID:NM_184043
Length:364
RefSeq Status:
Protein sequence is identical to GI:193794814 (mRNA isoform)
 
fructose-bisphosphate aldolase A isoform 2
Refseq ID:NP_001230106
Protein GI:342187211
UniProt ID:P04075
mRNA ID:NM_001243177
Length:418
RefSeq Status:
MARRKPEGSSFNMTHLSMAMAFSFPPVASGQLHPQLGNTQHQTELGKELATTSTMPYQYPALTPEQKKELSDIAHRIVAPGKGILAADESTGSIAKRLQS
IGTENTEENRRFYRQLLLTADDRVNPCIGGVILFHETLYQKADDGRPFPQVIKSKGGVVGIKVDKGVVPLAGTNGETTTQGLDGLSERCAQYKKDGADFA
KWRCVLKIGEHTPSALAIMENANVLARYASICQQNGIVPIVEPEILPDGDHDLKRCQYVTEKVLAAVYKALSDHHIYLEGTLLKPNMVTPGHACTQKFSH
EEIAMATVTALRRTVPPAVTGITFLSGGQSEEEASINLNAINKCPLLKPWALTFSYGRALQASALKAWGGKKENLKAAQEEYVKRALANSLACQGKYTPS
GQAGAAASESLFVSNHAY
 
  logo