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MGP000126

UniProt Annotations

Entry Information
Gene Namealdolase C, fructose-bisphosphate
Protein EntryALDOC_HUMAN
UniProt IDP09972
SpeciesHuman
Comments
Comment typeDescription
Biophysicochemical PropertiesKinetic parameters: KM=10.7 uM for fructose 1,6-bisphosphate {ECO:0000269|PubMed:15537755}; KM=16 mM for fructose 1-phosphate {ECO:0000269|PubMed:15537755};
Catalytic ActivityD-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate. {ECO:0000269|PubMed:15537755}.
MiscellaneousIn vertebrates, three forms of this ubiquitous glycolytic enzyme are found, aldolase A in muscle, aldolase B in liver and aldolase C in brain.
PathwayCarbohydrate degradation; glycolysis; D-glyceraldehyde 3- phosphate and glycerone phosphate from D-glucose: step 4/4.
Sequence CautionSequence=AAI03761.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the class I fructose-bisphosphate aldolase family. {ECO:0000305}.
SubunitHomotetramer. Interacts with ATP6V1E1. May interact with PLD2. {ECO:0000269|PubMed:11399750, ECO:0000269|PubMed:11876650}.
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