MGP Database

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MGP000128

Ontology/Pathway Information

Entrez Gene ID239
Gene Namearachidonate 12-lipoxygenase
Gene Symbol ALOX12
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 IDA:UniProtKBCcytoplasm
GO:0005829 IDA:UniProtKBCcytosol
GO:0070062 IDA:UniProtKBCextracellular vesicular exosome
GO:0016020 IDA:UniProtKBCmembrane
GO:0042383 IDA:UniProtKBCsarcolemma
GO:0004052 IDA:UniProtKBFarachidonate 12-lipoxygenase activity
GO:0051120 TAS:ReactomeFhepoxilin A3 synthase activity
GO:0047977 ISS:UniProtKBFhepoxilin-epoxide hydrolase activity
GO:0005506 IEA:InterProFiron ion binding
GO:0016165 IDA:UniProtKBFlinoleate 13S-lipoxygenase activity
GO:0016702 TAS:ReactomeFoxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GO:0007568 IEA:EnsemblPaging
GO:0019369 IDA:UniProtKBParachidonic acid metabolic process
GO:0006928 IMP:UniProtKBPcellular component movement
GO:0071396 IEA:EnsemblPcellular response to lipid
GO:0061436 ISS:UniProtKBPestablishment of skin barrier
GO:0019395 IMP:UniProtKBPfatty acid oxidation
GO:0051122 ISS:UniProtKBPhepoxilin biosynthetic process
GO:0051121 TAS:ReactomePhepoxilin metabolic process
GO:1901751 IDA:UniProtKBPleukotriene A4 metabolic process
GO:0043651 IDA:UniProtKBPlinoleic acid metabolic process
GO:2001303 IDA:UniProtKBPlipoxin A4 biosynthetic process
GO:2001306 IDA:UniProtKBPlipoxin B4 biosynthetic process
GO:2001300 TAS:ReactomePlipoxin metabolic process
GO:0019372 IDA:UniProtKBPlipoxygenase pathway
GO:0043066 IMP:UniProtKBPnegative regulation of apoptotic process
GO:0010656 IMP:UniProtKBPnegative regulation of muscle cell apoptotic process
GO:0090331 ISS:UniProtKBPnegative regulation of platelet aggregation
GO:0045766 IMP:UniProtKBPpositive regulation of angiogenesis
GO:0045785 IMP:UniProtKBPpositive regulation of cell adhesion
GO:0030307 IMP:UniProtKBPpositive regulation of cell growth
GO:0030335 IMP:UniProtKBPpositive regulation of cell migration
GO:0008284 IMP:UniProtKBPpositive regulation of cell proliferation
GO:0043280 IEA:EnsemblPpositive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045603 IEA:EnsemblPpositive regulation of endothelial cell differentiation
GO:0010595 IEA:EnsemblPpositive regulation of endothelial cell migration
GO:0010628 IEA:EnsemblPpositive regulation of gene expression
GO:0051901 IEA:EnsemblPpositive regulation of mitochondrial depolarization
GO:0048661 IEA:EnsemblPpositive regulation of smooth muscle cell proliferation
GO:0045909 IEA:EnsemblPpositive regulation of vasodilation
GO:0072593 NAS:UniProtKBPreactive oxygen species metabolic process
GO:0044281 TAS:ReactomePsmall molecule metabolic process
GO:0042554 NAS:UniProtKBPsuperoxide anion generation
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_147851Arachidonic acid metabolism
REACT_111217Metabolism
REACT_22258Metabolism of lipids and lipoproteins
REACT_150201Synthesis of 12-eicosatetraenoic acid derivatives
REACT_150292Synthesis of Hepoxilins (HX) and Trioxilins (TrX)
REACT_150320Synthesis of Lipoxins (LX)
SMP Pathway Links
SMP IDDescription
SMP00710Acetaminophen Action Pathway
SMP00083Acetylsalicylic Acid Action Pathway
SMP00692Antipyrine Action Pathway
SMP00693Antrafenine Action Pathway
SMP00075Arachidonic Acid Metabolism
SMP00102Bromfenac Action Pathway
SMP00694Carprofen Action Pathway
SMP00096Celecoxib Action Pathway
SMP00093Diclofenac Action Pathway
SMP00289Diflunisal Action Pathway
SMP00084Etodolac Action Pathway
SMP00695Etoricoxib Action Pathway
SMP00696Fenoprofen Action Pathway
SMP00697Flurbiprofen Action Pathway
SMP00086Ibuprofen Action Pathway
SMP00104Indomethacin Action Pathway
SMP00085Ketoprofen Action Pathway
SMP00098Ketorolac Action Pathway
SMP00353Leukotriene C4 Synthesis Deficiency
SMP00700Lornoxicam Action Pathway
SMP00699Lumiracoxib Action Pathway
SMP00698Magnesium salicylate Action Pathway
SMP00109Mefenamic Acid Action Pathway
SMP00106Meloxicam Action Pathway
SMP00114Nabumetone Action Pathway
SMP00120Naproxen Action Pathway
SMP00702Nepafenac Action Pathway
SMP00113Oxaprozin Action Pathway
SMP00701Phenylbutazone Action Pathway
SMP00077Piroxicam Action Pathway
SMP00087Rofecoxib Action Pathway
SMP00708Salicylate-sodium Action Pathway
SMP00709Salicylic Acid Action Pathway
SMP00707Salsalate Action Pathway
SMP00094Sulindac Action Pathway
SMP00101Suprofen Action Pathway
SMP00706Tenoxicam Action Pathway
SMP00705Tiaprofenic Acid Action Pathway
SMP00704Tolmetin Action Pathway
SMP00703Trisalicylate-choline Action Pathway
SMP00116Valdecoxib Action Pathway
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