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MGP000129

UniProt Annotations

Entry Information
Gene Namearachidonate 5-lipoxygenase
Protein EntryLOX5_HUMAN
UniProt IDP09917
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=5; Comment=Additional isoforms seem to exist.; Name=1; IsoId=P09917-1; Sequence=Displayed; Name=2; Synonyms=Delta-13; IsoId=P09917-2; Sequence=VSP_046998; Name=3; Synonyms=delta-p10; IsoId=P09917-3; Sequence=VSP_053534; Name=4; Synonyms=delta-10-13; IsoId=P09917-4; Sequence=VSP_053535, VSP_053537; Name=5; Synonyms=alpha-10; IsoId=P09917-5; Sequence=VSP_053536;
Catalytic ActivityArachidonate + O(2) = leukotriene A(4) + H(2)O. {ECO:0000269|PubMed:21233389}.
CofactorName=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000250}; Note=Binds 2 calcium ions per subunit. {ECO:0000250};
CofactorName=Fe cation; Xref=ChEBI:CHEBI:24875; Evidence={ECO:0000255|PROSITE-ProRule:PRU00726, ECO:0000269|PubMed:21233389}; Note=Binds 1 Fe cation per subunit. {ECO:0000255|PROSITE- ProRule:PRU00726, ECO:0000269|PubMed:21233389};
FunctionCatalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes. {ECO:0000269|PubMed:21233389}.
InteractionQ14019:COTL1; NbExp=4; IntAct=EBI-79934, EBI-79926; P09769:FGR; NbExp=2; IntAct=EBI-79934, EBI-1383732; P08631:HCK; NbExp=2; IntAct=EBI-79934, EBI-346340; P17612:PRKACA; NbExp=2; IntAct=EBI-79934, EBI-476586; P07947:YES1; NbExp=2; IntAct=EBI-79934, EBI-515331;
PathwayLipid metabolism; leukotriene A4 biosynthesis.
PtmSerine phosphorylation by MAPKAPK2 is stimulated by arachidonic acid. Phosphorylation on Ser-523 by PKA has an inhibitory effect. Phosphorylation on Ser-272 prevents export from the nucleus. {ECO:0000269|PubMed:11844797, ECO:0000269|PubMed:15280375, ECO:0000269|PubMed:18978352}.
SimilarityBelongs to the lipoxygenase family. {ECO:0000305}.
SimilarityContains 1 lipoxygenase domain. {ECO:0000255|PROSITE- ProRule:PRU00726}.
SimilarityContains 1 PLAT domain. {ECO:0000255|PROSITE- ProRule:PRU00152}.
Subcellular LocationCytoplasm. Nucleus matrix. Nucleus membrane; Peripheral membrane protein. Note=Shuttles between cytoplasm and nucleus. Found exclusively in the nucleus, when phosphorylated on Ser-272. Calcium binding promotes translocation from the cytosol and the nuclear matrix to the nuclear envelope and membrane association.
SubunitInteracts with ALOX5AP and LTC4S. Interacts with COTL1, the interaction is required for stability and efficient catalytic activity. {ECO:0000269|PubMed:19233132, ECO:0000269|PubMed:19807693, ECO:0000269|PubMed:21233389}.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/ALOX5ID42985ch10q11.html";
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