MGP Database

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MGP000132

Ontology/Pathway Information

Entrez Gene ID246
Gene Namearachidonate 15-lipoxygenase
Gene Symbol ALOX15
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005829 IDA:UniProtKBCcytosol
GO:0031234 IDA:UniProtKBCextrinsic component of cytoplasmic side of plasma membrane
GO:0005811 IDA:UniProtKBClipid particle
GO:0016020 IDA:UniProtKBCmembrane
GO:0005886 ISS:UniProtKBCplasma membrane
GO:0004052 IDA:UniProtKBFarachidonate 12-lipoxygenase activity
GO:0050473 IDA:UniProtKBFarachidonate 15-lipoxygenase activity
GO:0097260 TAS:ReactomeFeoxin A4 synthase activity
GO:0051120 IEA:EnsemblFhepoxilin A3 synthase activity
GO:0047977 IEA:EnsemblFhepoxilin-epoxide hydrolase activity
GO:0005506 ISS:UniProtKBFiron ion binding
GO:0005546 IDA:UniProtKBFphosphatidylinositol-4,5-bisphosphate binding
GO:0043277 ISS:UniProtKBPapoptotic cell clearance
GO:0019369 IDA:UniProtKBParachidonic acid metabolic process
GO:0030282 ISS:UniProtKBPbone mineralization
GO:0071277 IDA:UniProtKBPcellular response to calcium ion
GO:0035963 IMP:UniProtKBPcellular response to interleukin-13
GO:0051122 ISS:UniProtKBPhepoxilin biosynthetic process
GO:0006954 TAS:ProtIncPinflammatory response
GO:0006691 TAS:ReactomePleukotriene metabolic process
GO:2001303 ISS:UniProtKBPlipoxin A4 biosynthetic process
GO:0019372 IDA:UniProtKBPlipoxygenase pathway
GO:0002820 ISS:UniProtKBPnegative regulation of adaptive immune response
GO:0001503 ISS:UniProtKBPossification
GO:0006646 ISS:UniProtKBPphosphatidylethanolamine biosynthetic process
GO:0030838 ISS:UniProtKBPpositive regulation of actin filament polymerization
GO:0010811 IDA:UniProtKBPpositive regulation of cell-substrate adhesion
GO:0070374 IMP:UniProtKBPpositive regulation of ERK1 and ERK2 cascade
GO:0034116 IEA:EnsemblPpositive regulation of heterotypic cell-cell adhesion
GO:1901074 ISS:UniProtKBPregulation of engulfment of apoptotic cell
GO:0035358 ISS:UniProtKBPregulation of peroxisome proliferator activated receptor signaling pathway
GO:0034976 ISS:UniProtKBPresponse to endoplasmic reticulum stress
GO:0044281 TAS:ReactomePsmall molecule metabolic process
GO:0042060 ISS:UniProtKBPwound healing
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_147851Arachidonic acid metabolism
REACT_111217Metabolism
REACT_22258Metabolism of lipids and lipoproteins
REACT_150201Synthesis of 12-eicosatetraenoic acid derivatives
REACT_150422Synthesis of 15-eicosatetraenoic acid derivatives
REACT_150420Synthesis of Leukotrienes (LT) and Eoxins (EX)
SMP Pathway Links
SMP IDDescription
SMP00710Acetaminophen Action Pathway
SMP00083Acetylsalicylic Acid Action Pathway
SMP00692Antipyrine Action Pathway
SMP00693Antrafenine Action Pathway
SMP00075Arachidonic Acid Metabolism
SMP00102Bromfenac Action Pathway
SMP00694Carprofen Action Pathway
SMP00096Celecoxib Action Pathway
SMP00093Diclofenac Action Pathway
SMP00289Diflunisal Action Pathway
SMP00084Etodolac Action Pathway
SMP00695Etoricoxib Action Pathway
SMP00696Fenoprofen Action Pathway
SMP00697Flurbiprofen Action Pathway
SMP00086Ibuprofen Action Pathway
SMP00104Indomethacin Action Pathway
SMP00085Ketoprofen Action Pathway
SMP00098Ketorolac Action Pathway
SMP00353Leukotriene C4 Synthesis Deficiency
SMP00700Lornoxicam Action Pathway
SMP00699Lumiracoxib Action Pathway
SMP00698Magnesium salicylate Action Pathway
SMP00109Mefenamic Acid Action Pathway
SMP00106Meloxicam Action Pathway
SMP00114Nabumetone Action Pathway
SMP00120Naproxen Action Pathway
SMP00702Nepafenac Action Pathway
SMP00113Oxaprozin Action Pathway
SMP00701Phenylbutazone Action Pathway
SMP00077Piroxicam Action Pathway
SMP00087Rofecoxib Action Pathway
SMP00708Salicylate-sodium Action Pathway
SMP00709Salicylic Acid Action Pathway
SMP00707Salsalate Action Pathway
SMP00094Sulindac Action Pathway
SMP00101Suprofen Action Pathway
SMP00706Tenoxicam Action Pathway
SMP00705Tiaprofenic Acid Action Pathway
SMP00704Tolmetin Action Pathway
SMP00703Trisalicylate-choline Action Pathway
SMP00116Valdecoxib Action Pathway
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