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MGP000135

Record overview

MGPD IDMGP000135
Gene ID259
SpeciesHomo sapiens (Human)
Gene Namealpha-1-microglobulin/bikunin precursor
Gene Symbol AMBP
SynonymsA1M; HCP; ITI; UTI; EDC1; HI30; ITIL; IATIL; ITILC;
Alternate namesprotein AMBP; bikunin; uristatin; protein HC; trypstatin; uronic-acid-rich protein; growth-inhibiting protein 19; inter-alpha-trypsin inhibitor light chain; complex-forming glycoprotein heterogeneous in charge;
Chromosome9
Map Location9q32-q33
SummaryThis gene encodes a complex glycoprotein secreted in plasma. The precursor is proteolytically processed into distinct functioning proteins: alpha-1-microglobulin, which belongs to the superfamily of lipocalin transport proteins and may play a role in the regulation of inflammatory processes, and bikunin, which is a urinary trypsin inhibitor belonging to the superfamily of Kunitz-type protease inhibitors and plays an important role in many physiological and pathological processes. This gene is located on chromosome 9 in a cluster of lipocalin genes. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for AMBP

Proteins

protein AMBP preproprotein
Refseq ID:NP_001624
Protein GI:4502067
UniProt ID:P02760
mRNA ID:NM_001633
Length:352
RefSeq Status:
MRSLGALLLLLSACLAVSAGPVPTPPDNIQVQENFNISRIYGKWYNLAIGSTCPWLKKIMDRMTVSTLVLGEGATEAEISMTSTRWRKGVCEETSGAYEK
TDTDGKFLYHKSKWNITMESYVVHTNYDEYAIFLTKKFSRHHGPTITAKLYGRAPQLRETLLQDFRVVAQGVGIPEDSIFTMADRGECVPGEQEPEPILI
PRVRRAVLPQEEEGSGGGQLVTEVTKKEDSCQLGYSAGPCMGMTSRYFYNGTSMACETFQYGGCMGNGNNFVTEKECLQTCRTVAACNLPIVRGPCRAFI
QLWAFDAVKGKCVLFPYGGCQGNGNKFYSEKECREYCGVPGDGDEELLRFSN
 
sig_peptide: 1..19
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 1902
peptide sequence: 
MRSLGALLLLLSACLAVSA

mat_peptide: 20..203
product: alpha-1-microglobulin
calculated_mol_wt: 20847
peptide sequence: 
GPVPTPPDNIQVQENFNISRIYGKWYNLAIGSTCPWLKKIMDRMTVSTLVLGEGATEAEISMTSTRWRKGVCEETSGAYEKTDTDGKFLYHKSKWNITME
SYVVHTNYDEYAIFLTKKFSRHHGPTITAKLYGRAPQLRETLLQDFRVVAQGVGIPEDSIFTMADRGECVPGEQEPEPILIPRV

mat_peptide: 206..352
product: bikunin
calculated_mol_wt: 15974
peptide sequence: 
AVLPQEEEGSGGGQLVTEVTKKEDSCQLGYSAGPCMGMTSRYFYNGTSMACETFQYGGCMGNGNNFVTEKECLQTCRTVAACNLPIVRGPCRAFIQLWAF
DAVKGKCVLFPYGGCQGNGNKFYSEKECREYCGVPGDGDEELLRFSN

mat_peptide: 284..344
product: trypstatin
calculated_mol_wt: 6620
peptide sequence: 
VAACNLPIVRGPCRAFIQLWAFDAVKGKCVLFPYGGCQGNGNKFYSEKECREYCGVPGDGD
 
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