MGP Database

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MGP000136

Record overview

MGPD IDMGP000136
Gene ID262
SpeciesHomo sapiens (Human)
Gene Nameadenosylmethionine decarboxylase 1
Gene Symbol AMD1
SynonymsAMD; SAMDC; ADOMETDC;
Alternate namesS-adenosylmethionine decarboxylase proenzyme; S-adenosylmethionine decarboxylase 1;
Chromosome6
Map Location6q21
EC Number4.1.1.50
SummaryThis gene encodes an important intermediate enzyme in polyamine biosynthesis. The polyamines spermine, spermidine, and putrescine are low-molecular-weight aliphatic amines essential for cellular proliferation and tumor promotion. Multiple alternatively spliced transcript variants have been identified. Pseudogenes of this gene are found on chromosomes 5, 6, 10, X and Y. [provided by RefSeq, Dec 2013]
OrthologsView orthologs and multiple alignments for AMD1

Proteins

S-adenosylmethionine decarboxylase proenzyme isoform 1
Refseq ID:NP_001625
Protein GI:74275346
UniProt ID:P17707
mRNA ID:NM_001634
Length:334
RefSeq Status:
MEAAHFFEGTEKLLEVWFSRQQPDANQGSGDLRTIPRSEWDILLKDVQCSIISVTKTDKQEAYVLSESSMFVSKRRFILKTCGTTLLLKALVPLLKLARD
YSGFDSIQSFFYSRKNFMKPSHQGYPHRNFQEEIEFLNAIFPNGAAYCMGRMNSDCWYLYTLDFPESRVISQPDQTLEILMSELDPAVMDQFYMKDGVTA
KDVTRESGIRDLIPGSVIDATMFNPCGYSMNGMKSDGTYWTIHITPEPEFSYVSFETNLSQTSYDDLIRKVVEVFKPGKFVTTLFVNQSSKCRTVLASPQ
KIEGFKRLDCQSAMFNDYNFVFTSFAKKQQQQQS
 
mat_peptide: 1..67
product: S-adenosylmethionine decarboxylase beta chain
calculated_mol_wt: 7687
peptide sequence: 
MEAAHFFEGTEKLLEVWFSRQQPDANQGSGDLRTIPRSEWDILLKDVQCSIISVTKTDKQEAYVLSE

mat_peptide: 68..334
product: S-adenosylmethionine decarboxylase alpha chain
calculated_mol_wt: 30671
peptide sequence: 
SSMFVSKRRFILKTCGTTLLLKALVPLLKLARDYSGFDSIQSFFYSRKNFMKPSHQGYPHRNFQEEIEFLNAIFPNGAAYCMGRMNSDCWYLYTLDFPES
RVISQPDQTLEILMSELDPAVMDQFYMKDGVTAKDVTRESGIRDLIPGSVIDATMFNPCGYSMNGMKSDGTYWTIHITPEPEFSYVSFETNLSQTSYDDL
IRKVVEVFKPGKFVTTLFVNQSSKCRTVLASPQKIEGFKRLDCQSAMFNDYNFVFTSFAKKQQQQQS
 
S-adenosylmethionine decarboxylase proenzyme isoform 3
Refseq ID:NP_001274143
Protein GI:564473397
UniProt ID:B4DZ60
mRNA ID:NM_001287214
Length:305
RefSeq Status:
MEAAHFFEGTEKLLEVWFSRQQPDANQGSGDLRTIPSESSMFVSKRRFILKTCGTTLLLKALVPLLKLARDYSGFDSIQSFFYSRKNFMKPSHQGYPHRN
FQEEIEFLNAIFPNGAAYCMGRMNSDCWYLYTLDFPESRVISQPDQTLEILMSELDPAVMDQFYMKDGVTAKDVTRESGIRDLIPGSVIDATMFNPCGYS
MNGMKSDGTYWTIHITPEPEFSYVSFETNLSQTSYDDLIRKVVEVFKPGKFVTTLFVNQSSKCRTVLASPQKIEGFKRLDCQSAMFNDYNFVFTSFAKKQ
QQQQS
 
mat_peptide: 1..67
product: S-adenosylmethionine decarboxylase beta chain
calculated_mol_wt: 7687
peptide sequence: 
MEAAHFFEGTEKLLEVWFSRQQPDANQGSGDLRTIPRSEWDILLKDVQCSIISVTKTDKQEAYVLSE

mat_peptide: 68..334
product: S-adenosylmethionine decarboxylase alpha chain
calculated_mol_wt: 30671
peptide sequence: 
SSMFVSKRRFILKTCGTTLLLKALVPLLKLARDYSGFDSIQSFFYSRKNFMKPSHQGYPHRNFQEEIEFLNAIFPNGAAYCMGRMNSDCWYLYTLDFPES
RVISQPDQTLEILMSELDPAVMDQFYMKDGVTAKDVTRESGIRDLIPGSVIDATMFNPCGYSMNGMKSDGTYWTIHITPEPEFSYVSFETNLSQTSYDDL
IRKVVEVFKPGKFVTTLFVNQSSKCRTVLASPQKIEGFKRLDCQSAMFNDYNFVFTSFAKKQQQQQS
 
S-adenosylmethionine decarboxylase proenzyme isoform 4
Refseq ID:NP_001274144
Protein GI:564473399
UniProt ID:Q5VXN5
mRNA ID:NM_001287215
Length:265
RefSeq Status:
MFVSKRRFILKTCGTTLLLKALVPLLKLARDYSGFDSIQSFFYSRKNFMKPSHQGYPHRNFQEEIEFLNAIFPNGAAYCMGRMNSDCWYLYTLDFPESRV
ISQPDQTLEILMSELDPAVMDQFYMKDGVTAKDVTRESGIRDLIPGSVIDATMFNPCGYSMNGMKSDGTYWTIHITPEPEFSYVSFETNLSQTSYDDLIR
KVVEVFKPGKFVTTLFVNQSSKCRTVLASPQKIEGFKRLDCQSAMFNDYNFVFTSFAKKQQQQQS
 
mat_peptide: 1..67
product: S-adenosylmethionine decarboxylase beta chain
calculated_mol_wt: 7687
peptide sequence: 
MEAAHFFEGTEKLLEVWFSRQQPDANQGSGDLRTIPRSEWDILLKDVQCSIISVTKTDKQEAYVLSE

mat_peptide: 68..334
product: S-adenosylmethionine decarboxylase alpha chain
calculated_mol_wt: 30671
peptide sequence: 
SSMFVSKRRFILKTCGTTLLLKALVPLLKLARDYSGFDSIQSFFYSRKNFMKPSHQGYPHRNFQEEIEFLNAIFPNGAAYCMGRMNSDCWYLYTLDFPES
RVISQPDQTLEILMSELDPAVMDQFYMKDGVTAKDVTRESGIRDLIPGSVIDATMFNPCGYSMNGMKSDGTYWTIHITPEPEFSYVSFETNLSQTSYDDL
IRKVVEVFKPGKFVTTLFVNQSSKCRTVLASPQKIEGFKRLDCQSAMFNDYNFVFTSFAKKQQQQQS
 
S-adenosylmethionine decarboxylase proenzyme isoform 5
Refseq ID:NP_001274145
Protein GI:564473401
UniProt ID:B4DZ60
mRNA ID:NM_001287216
Length:214
RefSeq Status:
MEAAHFFEGTEKLLEVWFSRQQPDANQGSGDLRTIPRYLYTLDFPESRVISQPDQTLEILMSELDPAVMDQFYMKDGVTAKDVTRESGIRDLIPGSVIDA
TMFNPCGYSMNGMKSDGTYWTIHITPEPEFSYVSFETNLSQTSYDDLIRKVVEVFKPGKFVTTLFVNQSSKCRTVLASPQKIEGFKRLDCQSAMFNDYNF
VFTSFAKKQQQQQS
 
mat_peptide: 1..67
product: S-adenosylmethionine decarboxylase beta chain
calculated_mol_wt: 7687
peptide sequence: 
MEAAHFFEGTEKLLEVWFSRQQPDANQGSGDLRTIPRSEWDILLKDVQCSIISVTKTDKQEAYVLSE

mat_peptide: 68..334
product: S-adenosylmethionine decarboxylase alpha chain
calculated_mol_wt: 30671
peptide sequence: 
SSMFVSKRRFILKTCGTTLLLKALVPLLKLARDYSGFDSIQSFFYSRKNFMKPSHQGYPHRNFQEEIEFLNAIFPNGAAYCMGRMNSDCWYLYTLDFPES
RVISQPDQTLEILMSELDPAVMDQFYMKDGVTAKDVTRESGIRDLIPGSVIDATMFNPCGYSMNGMKSDGTYWTIHITPEPEFSYVSFETNLSQTSYDDL
IRKVVEVFKPGKFVTTLFVNQSSKCRTVLASPQKIEGFKRLDCQSAMFNDYNFVFTSFAKKQQQQQS
 
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