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MGP000152

Record overview

MGPD IDMGP000152
Gene ID291
SpeciesHomo sapiens (Human)
Gene Namesolute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
Gene Symbol SLC25A4
Synonyms1; T1; ANT; AAC1; ANT1; PEO2; PEO3; ANT 1; MTDPS12;
Alternate namesADP/ATP translocase 1; ADP,ATP carrier protein 1; ADP,ATP carrier protein, heart/skeletal muscle; adenine nucleotide translocator 1 (skeletal muscle); heart/skeletal muscle ATP/ADP translocator; solute carrier family 25 member 4;
Chromosome4
Map Location4q35
SummaryThis gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the cytoplasm into the mitochondrial matrix and ATP from the mitochondrial matrix into the cytoplasm. The protein forms a homodimer embedded in the inner mitochondria membrane. Mutations in this gene have been shown to result in autosomal dominant progressive external opthalmoplegia and familial hypertrophic cardiomyopathy. [provided by RefSeq, Jun 2013]
OrthologsView orthologs and multiple alignments for SLC25A4

Proteins

ADP/ATP translocase 1
Refseq ID:NP_001142
Protein GI:55749577
UniProt ID:P12235
mRNA ID:NM_001151
Length:298
RefSeq Status:
MGDHAWSFLKDFLAGGVAAAVSKTAVAPIERVKLLLQVQHASKQISAEKQYKGIIDCVVRIPKEQGFLSFWRGNLANVIRYFPTQALNFAFKDKYKQLFL
GGVDRHKQFWRYFAGNLASGGAAGATSLCFVYPLDFARTRLAADVGKGAAQREFHGLGDCIIKIFKSDGLRGLYQGFNVSVQGIIIYRAAYFGVYDTAKG
MLPDPKNVHIFVSWMIAQSVTAVAGLVSYPFDTVRRRMMMQSGRKGADIMYTGTVDCWRKIAKDEGAKAFFKGAWSNVLRGMGGAFVLVLYDEIKKYV
 
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