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MGP000164

Record overview

MGPD IDMGP000164
Gene ID330
SpeciesHomo sapiens (Human)
Gene Namebaculoviral IAP repeat containing 3
Gene Symbol BIRC3
SynonymsAIP1; API2; MIHC; CIAP2; HAIP1; HIAP1; MALT2; RNF49; c-IAP2;
Alternate namesbaculoviral IAP repeat-containing protein 3; IAP-1; IAP homolog C; apoptosis inhibitor 2; RING finger protein 49; mammalian IAP homolog C; inhibitor of apoptosis protein 1; baculoviral IAP repeat-containing 3; TNFR2-TRAF signaling complex protein; TNFR2-TRAF-signaling complex protein 1;
Chromosome11
Map Location11q22
EC Number6.3.2.-
SummaryThis gene encodes a member of the IAP family of proteins that inhibit apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. It contains 3 baculovirus IAP repeats and a ring finger domain. Transcript variants encoding the same isoform have been identified. [provided by RefSeq, Aug 2011]
OrthologsView orthologs and multiple alignments for BIRC3

Proteins

baculoviral IAP repeat-containing protein 3
Refseq ID:NP_892007
Protein GI:33946285
UniProt ID:Q13489
mRNA ID:NM_182962
Length:604
RefSeq Status:
MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLN
SVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPG
DRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLR
CWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQ
RKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTIL
VKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVR
TFLS
 
baculoviral IAP repeat-containing protein 3
Refseq ID:NP_001156
Protein GI:4502139
UniProt ID:Q13489
mRNA ID:NM_001165
Length:604
RefSeq Status:
Protein sequence is identical to GI:33946285 (mRNA isoform)
 
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