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MGP000166

Record overview

MGPD IDMGP000166
Gene ID332
SpeciesHomo sapiens (Human)
Gene Namebaculoviral IAP repeat containing 5
Gene Symbol BIRC5
SynonymsAPI4; EPR-1;
Alternate namesbaculoviral IAP repeat-containing protein 5; apoptosis inhibitor 4; survivin variant 3 alpha; apoptosis inhibitor survivin;
Chromosome17
Map Location17q25
SummaryThis gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2011]
OrthologsView orthologs and multiple alignments for BIRC5

Proteins

baculoviral IAP repeat-containing protein 5 isoform 1
Refseq ID:NP_001159
Protein GI:59859878
UniProt ID:O15392
mRNA ID:NM_001168
Length:142
RefSeq Status:
MGAPTLPPAWQPFLKDHRISTFKNWPFLEGCACTPERMAEAGFIHCPTENEPDLAQCFFCFKELEGWEPDDDPIEEHKKHSSGCAFLSVKKQFEELTLGE
FLKLDRERAKNKIAKETNNKKKEFEETAEKVRRAIEQLAAMD
 
baculoviral IAP repeat-containing protein 5 isoform 2
Refseq ID:NP_001012270
Protein GI:59859880
UniProt ID:O15392
mRNA ID:NM_001012270
Length:137
RefSeq Status:
MGAPTLPPAWQPFLKDHRISTFKNWPFLEGCACTPERMAEAGFIHCPTENEPDLAQCFFCFKELEGWEPDDDPMQRKPTIRRKNLRKLRRKCAVPSSSWL
PWIEASGRSCLVPEWLHHFQGLFPGATSLPVGPLAMS
 
baculoviral IAP repeat-containing protein 5 isoform 3
Refseq ID:NP_001012271
Protein GI:59859882
UniProt ID:O15392
mRNA ID:NM_001012271
Length:165
RefSeq Status:
MGAPTLPPAWQPFLKDHRISTFKNWPFLEGCACTPERMAEAGFIHCPTENEPDLAQCFFCFKELEGWEPDDDPIGPGTVAYACNTSTLGGRGGRITREEH
KKHSSGCAFLSVKKQFEELTLGEFLKLDRERAKNKIAKETNNKKKEFEETAEKVRRAIEQLAAMD
 
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