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MGP000167

Record overview

MGPD IDMGP000167
Gene ID335
SpeciesHomo sapiens (Human)
Gene Nameapolipoprotein A-I
Gene Symbol APOA1
Alternate namesapolipoprotein A-I; apo-AI;
Chromosome11
Map Location11q23-q24
SummaryThis gene encodes apolipoprotein A-I, which is the major protein component of high density lipoprotein (HDL) in plasma. The protein promotes cholesterol efflux from tissues to the liver for excretion, and it is a cofactor for lecithin cholesterolacyltransferase (LCAT) which is responsible for the formation of most plasma cholesteryl esters. This gene is closely linked with two other apolipoprotein genes on chromosome 11. Defects in this gene are associated with HDL deficiencies, including Tangier disease, and with systemic non-neuropathic amyloidosis. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for APOA1

Proteins

apolipoprotein A-I preproprotein
Refseq ID:NP_000030
Protein GI:4557321
UniProt ID:P02647
mRNA ID:NM_000039
Length:267
RefSeq Status:
MKAAVLTLAVLFLTGSQARHFWQQDEPPQSPWDRVKDLATVYVDVLKDSGRDYVSQFEGSALGKQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLE
KETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRARAHVDALRTHLAPYSDELRQRLAA
RLEALKENGGARLAEYHAKATEHLSTLSEKAKPALEDLRQGLLPVLESFKVSFLSALEEYTKKLNTQ
 
sig_peptide: 1..18
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 1834
peptide sequence: 
MKAAVLTLAVLFLTGSQA

mat_peptide: 19..267
product: Proapolipoprotein A-I
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P02647.1)
calculated_mol_wt: 28962
peptide sequence: 
RHFWQQDEPPQSPWDRVKDLATVYVDVLKDSGRDYVSQFEGSALGKQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVK
AKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRARAHVDALRTHLAPYSDELRQRLAARLEALKENGGARLAEYHA
KATEHLSTLSEKAKPALEDLRQGLLPVLESFKVSFLSALEEYTKKLNTQ

mat_peptide: 25..267
product: apolipoprotein A-I
calculated_mol_wt: 28079
peptide sequence: 
DEPPQSPWDRVKDLATVYVDVLKDSGRDYVSQFEGSALGKQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAKVQPY
LDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRARAHVDALRTHLAPYSDELRQRLAARLEALKENGGARLAEYHAKATEHL
STLSEKAKPALEDLRQGLLPVLESFKVSFLSALEEYTKKLNTQ

mat_peptide: 25..266
product: Truncated apolipoprotein A-I
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P02647.1)
calculated_mol_wt: 27951
peptide sequence: 
DEPPQSPWDRVKDLATVYVDVLKDSGRDYVSQFEGSALGKQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAKVQPY
LDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRARAHVDALRTHLAPYSDELRQRLAARLEALKENGGARLAEYHAKATEHL
STLSEKAKPALEDLRQGLLPVLESFKVSFLSALEEYTKKLNT
 
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