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MGP000174

UniProt Annotations

Entry Information
Gene Nameapolipoprotein D
Protein EntryAPOD_HUMAN
UniProt IDP05090
SpeciesHuman
Comments
Comment typeDescription
FunctionAPOD occurs in the macromolecular complex with lecithin- cholesterol acyltransferase. It is probably involved in the transport and binding of bilin. Appears to be able to transport a variety of ligands in a number of different contexts.
MiscellaneousAPOD is primarily localized in HDL (60-65%), with most of the remainder in VHDL and only trace amounts in VLDL and LDL.
PtmN-glycosylatd. N-glycan heterogeneity at Asn-65: Hex5HexNAc4 (major) and Hex6HexNAc5 (minor); at Asn-98: Hex5HexNAc4 (minor), dHex1Hex5HexNAc4 (major), dHex1Hex6HexNAc5 (minor) and dHex1Hex7HexNAc6 (minor). {ECO:0000269|PubMed:14760718, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19139490, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19838169, ECO:0000269|PubMed:22171320, ECO:0000269|PubMed:7613477, ECO:0000269|PubMed:7918467}.
SimilarityBelongs to the calycin superfamily. Lipocalin family. {ECO:0000305}.
Subcellular LocationSecreted.
SubunitHomodimer. In plasma, also exists as a disulfide-linked heterodimer with APOA2. {ECO:0000269|PubMed:7918467}.
Tissue SpecificityExpressed in liver, intestine, pancreas, kidney, placenta, adrenal, spleen, fetal brain tissue and tears.
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