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MGP000178

UniProt Annotations

Entry Information
Gene Namekallikrein-related peptidase 3
Protein EntryKLK3_HUMAN
UniProt IDP07288
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=5; Name=1; IsoId=P07288-1; Sequence=Displayed; Name=2; IsoId=P07288-2; Sequence=VSP_045786; Note=No experimental confirmation available.; Name=3; IsoId=P07288-3; Sequence=VSP_046169, VSP_046171; Note=No experimental confirmation available.; Name=4; IsoId=P07288-4; Sequence=VSP_046169, VSP_046170; Note=No experimental confirmation available.; Name=5; IsoId=P07288-5; Sequence=VSP_047643;
Catalytic ActivityPreferential cleavage: -Tyr-|-Xaa-.
Enzyme RegulationInhibited by SERPINA5. Activity is strongly inhibited by Zn2+, 100 times more abundant in semen than in serum. This inhibition is relieved by exposure to semenogelins, which are avid zinc binders. {ECO:0000269|PubMed:1725227, ECO:0000269|PubMed:18187150}.
FunctionHydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum.
InteractionP10275:AR; NbExp=3; IntAct=EBI-1220791, EBI-608057;
Sequence CautionSequence=AAD14185.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAA32124.1; Type=Miscellaneous discrepancy; Evidence={ECO:0000305};
SimilarityBelongs to the peptidase S1 family. Kallikrein subfamily. {ECO:0000255|PROSITE-ProRule:PRU00274}.
SimilarityContains 1 peptidase S1 domain. {ECO:0000255|PROSITE- ProRule:PRU00274}.
Subcellular LocationSecreted.
SubunitForms a heterodimer with SERPINA5. {ECO:0000269|PubMed:18187150}.
Web ResourceName=Wikipedia; Note=Prostate-specific antigen entry; URL="http://en.wikipedia.org/wiki/Prostate_specific_antigen";
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