MGP Database

MGP000179

Ontology/Pathway Information

Entrez Gene ID	355
Gene Name	Fas cell surface death receptor
Gene Symbol	FAS
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0031265	IDA:UniProtKB	C	CD95 death-inducing signaling complex
GO:0009986	IDA:UniProtKB	C	cell surface
GO:0005737	IDA:HPA	C	cytoplasm
GO:0005829	NAS:UniProtKB	C	cytosol
GO:0031264	IDA:UniProtKB	C	death-inducing signaling complex
GO:0009897	IEA:Ensembl	C	external side of plasma membrane
GO:0070062	IDA:UniProtKB	C	extracellular vesicular exosome
GO:0016021	IEA:UniProtKB-KW	C	integral component of membrane
GO:0045121	IDA:UniProtKB	C	membrane raft
GO:0005634	IDA:HPA	C	nucleus
GO:0005886	IMP:UniProtKB	C	plasma membrane
GO:0042802	IPI:IntAct	F	identical protein binding
GO:0019900	IPI:BHF-UCL	F	kinase binding
GO:0004872	NAS:UniProtKB	F	receptor activity
GO:0004871	TAS:ProtInc	F	signal transducer activity
GO:0004888	IEA:InterPro	F	transmembrane signaling receptor activity
GO:0006924	IEA:Ensembl	P	activation-induced cell death of T cells
GO:0006919	TAS:Reactome	P	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006915	IDA:MGI	P	apoptotic process
GO:0097190	TAS:Reactome	P	apoptotic signaling pathway
GO:0019724	IEA:Ensembl	P	B cell mediated immunity
GO:0071455	IMP:UniProtKB	P	cellular response to hyperoxia
GO:0071285	IEA:Ensembl	P	cellular response to lithium ion
GO:0071260	IEP:UniProtKB	P	cellular response to mechanical stimulus
GO:0007623	IEA:Ensembl	P	circadian rhythm
GO:0097191	IMP:UniProtKB	P	extrinsic apoptotic signaling pathway
GO:0097192	IEA:Ensembl	P	extrinsic apoptotic signaling pathway in absence of ligand
GO:0008625	IEA:Ensembl	P	extrinsic apoptotic signaling pathway via death domain receptors
GO:0002377	IEA:Ensembl	P	immunoglobulin production
GO:0006925	IEA:Ensembl	P	inflammatory cell apoptotic process
GO:0097049	IEA:Ensembl	P	motor neuron apoptotic process
GO:0097527	IMP:BHF-UCL	P	necroptotic signaling pathway
GO:0043066	TAS:ProtInc	P	negative regulation of apoptotic process
GO:0050869	IEA:Ensembl	P	negative regulation of B cell activation
GO:0045060	IEA:Ensembl	P	negative thymic T cell selection
GO:0043065	IDA:UniProtKB	P	positive regulation of apoptotic process
GO:2001241	IEA:Ensembl	P	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:0032464	IEA:Ensembl	P	positive regulation of protein homooligomerization
GO:0006461	TAS:ProtInc	P	protein complex assembly
GO:0051260	IEA:Ensembl	P	protein homooligomerization
GO:0042981	NAS:UniProtKB	P	regulation of apoptotic process
GO:2001239	TAS:Reactome	P	regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:0045619	IEA:Ensembl	P	regulation of lymphocyte differentiation
GO:0045637	IEA:Ensembl	P	regulation of myeloid cell differentiation
GO:0003014	IEA:Ensembl	P	renal system process
GO:0051384	IEA:Ensembl	P	response to glucocorticoid
GO:0009636	IEA:Ensembl	P	response to toxic substance
GO:0007165	TAS:ProtInc	P	signal transduction
GO:0048536	IEA:Ensembl	P	spleen development
GO:0006927	IEA:Ensembl	P	transformed cell apoptotic process

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_1619	Death Receptor Signalling
REACT_1059	Extrinsic Pathway
REACT_900	FasL/ CD95L signaling
REACT_268456	Programmed Cell Death