MGP Database

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MGP000188

UniProt Annotations

Entry Information
Gene Nameaquaporin 9
Protein EntryAQP9_HUMAN
UniProt IDO43315
SpeciesHuman
Comments
Comment typeDescription
DomainAquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
FunctionForms a channel with a broad specificity. Mediates passage of a wide variety of non-charged solutes including carbamides, polyols, purines, and pyrimidines in a phloretin- and mercury-sensitive manner, whereas amino acids, cyclic sugars, Na(+), K(+), Cl(-), and deprotonated monocarboxylates are excluded. Also permeable to urea and glycerol. {ECO:0000269|PubMed:10564231}.
SimilarityBelongs to the MIP/aquaporin (TC 1.A.8) family. {ECO:0000305}.
Subcellular LocationMembrane; Multi-pass membrane protein.
Tissue SpecificityHighly expressed in peripheral leukocytes. Also expressed in liver, lung, and spleen.
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