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MGP000194

Record overview

MGPD IDMGP000194
Gene ID378
SpeciesHomo sapiens (Human)
Gene NameADP-ribosylation factor 4
Gene Symbol ARF4
SynonymsARF2;
Alternate namesADP-ribosylation factor 4; ADP-ribosylation factor 2;
Chromosome3
Map Location3p14.3
SummaryThis gene is a member of the human ARF gene family whose members encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The gene products include 5 ARF proteins and 11 ARF-like proteins and constitute one family of the RAS superfamily. The ARF proteins are categorized as class I, class II and class III; this gene is a class II member. The members of each class share a common gene organization. The ARF4 gene spans approximately 12kb and contains six exons and five introns. This gene is the most divergent member of the human ARFs. Conflicting map positions at 3p14 or 3p21 have been reported for this gene. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for ARF4

Proteins

ADP-ribosylation factor 4
Refseq ID:NP_001651
Protein GI:4502205
UniProt ID:P18085
mRNA ID:NM_001660
Length:180
RefSeq Status:
MGLTISSLFSRLFGKKQMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKNICFTVWDVGGQDRIRPLWKHYFQNTQGLIFVVDSNDRERI
QEVADELQKMLLVDELRDAVLLLFANKQDLPNAMAISEMTDKLGLQSLRNRTWYVQATCATQGTGLYEGLDWLSNELSKR
 
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