MGP Database

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MGP000196

UniProt Annotations

Entry Information
Gene Namearginase 2
Protein EntryARGI2_HUMAN
UniProt IDP78540
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityL-arginine + H(2)O = L-ornithine + urea.
CofactorName=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000255|PROSITE-ProRule:PRU00742, ECO:0000269|PubMed:12859189}; Note=Binds 2 manganese ions per subunit. {ECO:0000255|PROSITE- ProRule:PRU00742, ECO:0000269|PubMed:12859189};
FunctionMay play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to NO synthase. Since NO synthase is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase II plays a role in both male and female sexual arousal. It is therefore a potential target for the treatment of male and female sexual arousal disorders. {ECO:0000269|PubMed:12859189}.
PathwayNitrogen metabolism; urea cycle; L-ornithine and urea from L-arginine: step 1/1.
SimilarityBelongs to the arginase family. {ECO:0000255|PROSITE- ProRule:PRU00742}.
Subcellular LocationMitochondrion.
SubunitHomotrimer. {ECO:0000269|PubMed:12859189}.
Tissue SpecificityExpressed most strongly in kidney and prostate, much less strongly in the brain, skeletal muscle, placenta, lung, mammary gland, macrophage, uterus, testis and gut, but apparently not in the liver, heart and pancreas.
Web ResourceName=Wikipedia; Note=Arginase entry; URL="http://en.wikipedia.org/wiki/Arginase";
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