MGP Database

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MGP000197

Ontology/Pathway Information

Entrez Gene ID387
Gene Nameras homolog family member A
Gene Symbol RHOA
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0043296 IDA:UniProtKBCapical junction complex
GO:0005938 IDA:UniProtKBCcell cortex
GO:0030054 TAS:ReactomeCcell junction
GO:0032154 IEA:UniProtKB-SubCellCcleavage furrow
GO:0005856 IEA:UniProtKB-SubCellCcytoskeleton
GO:0005829 TAS:ReactomeCcytosol
GO:0070062 IDA:UniProtKBCextracellular vesicular exosome
GO:0005925 IDA:UniProtKBCfocal adhesion
GO:0030027 ISS:UniProtKBClamellipodium
GO:0030496 IEA:UniProtKB-SubCellCmidbody
GO:0005886 TAS:ReactomeCplasma membrane
GO:0003924 TAS:UniProtKBFGTPase activity
GO:0005525 IEA:UniProtKB-KWFGTP binding
GO:0017022 IPI:UniProtKBFmyosin binding
GO:0030036 TAS:UniProtKBPactin cytoskeleton organization
GO:0043297 IMP:UniProtKBPapical junction assembly
GO:0038027 IMP:UniProtKBPapolipoprotein A-I-mediated signaling pathway
GO:0007411 TAS:ReactomePaxon guidance
GO:0007596 TAS:ReactomePblood coagulation
GO:0036089 IDA:UniProtKBPcleavage furrow formation
GO:0006184 TAS:GOCPGTP catabolic process
GO:0050919 IMP:UniProtKBPnegative chemotaxis
GO:0050771 TAS:ReactomePnegative regulation of axonogenesis
GO:0048011 TAS:ReactomePneurotrophin TRK receptor signaling pathway
GO:0043931 ISS:BHF-UCLPossification involved in bone maturation
GO:0048015 TAS:ReactomePphosphatidylinositol-mediated signaling
GO:0030168 TAS:ReactomePplatelet activation
GO:0050772 TAS:ReactomePpositive regulation of axonogenesis
GO:0032467 IMP:UniProtKBPpositive regulation of cytokinesis
GO:0043123 IEP:UniProtKBPpositive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045666 IMP:MGIPpositive regulation of neuron differentiation
GO:0042346 NAS:UniProtKBPpositive regulation of NF-kappaB import into nucleus
GO:0051496 IDA:MGIPpositive regulation of stress fiber assembly
GO:0050770 TAS:ReactomePregulation of axonogenesis
GO:0030334 IMP:UniProtKBPregulation of cell migration
GO:0033688 ISS:BHF-UCLPregulation of osteoblast proliferation
GO:0051056 TAS:ReactomePregulation of small GTPase mediated signal transduction
GO:0007266 TAS:UniProtKBPRho protein signal transduction
GO:0007264 TAS:ReactomePsmall GTPase mediated signal transduction
GO:0090307 IMP:BHF-UCLPspindle assembly involved in mitosis
GO:0021762 IEP:UniProtKBPsubstantia nigra development
GO:0061383 ISS:BHF-UCLPtrabecula morphogenesis
GO:0007179 TAS:ReactomePtransforming growth factor beta receptor signaling pathway
GO:0016032 IEA:UniProtKB-KWPviral process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_13815Axonal growth inhibition (RHOA activation)
REACT_13779Axonal growth stimulation
REACT_18266Axon guidance
REACT_264224beta-catenin independent WNT signaling
REACT_111045Developmental Biology
REACT_116125Disease
REACT_264548EPHA-mediated growth cone collapse
REACT_263952EPHB-mediated forward signaling
REACT_264068EPH-Ephrin signaling
REACT_18407G alpha (12/13) signalling events
REACT_19290G beta:gamma signalling through PI3Kgamma
REACT_19184GPCR downstream signaling
REACT_19388G-protein beta:gamma signalling
REACT_1695GPVI-mediated activation cascade
REACT_604Hemostasis
REACT_169398Loss of Function of SMAD2/3 in Cancer
REACT_169219Loss of Function of SMAD4 in Cancer
REACT_169311Loss of Function of TGFBR1 in Cancer
REACT_169435Loss of Function of TGFBR2 in Cancer
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_13776p75 NTR receptor-mediated signalling
REACT_13620p75NTR regulates axonogenesis
REACT_264199PCP/CE pathway
REACT_12464PI3K/AKT activation
REACT_798Platelet activation, signaling and aggregation
REACT_11051Rho GTPase cycle
REACT_19277Sema4D induced cell migration and growth-cone collapse
REACT_19259Sema4D in semaphorin signaling
REACT_19266Sema4D mediated inhibition of cell attachment and migration
REACT_19271Semaphorin interactions
REACT_14797Signaling by GPCR
REACT_11044Signaling by Rho GTPases
REACT_6844Signaling by TGF-beta Receptor Complex
REACT_169122Signaling by TGF-beta Receptor Complex in Cancer
REACT_12529Signaling by VEGF
REACT_11045Signaling by Wnt
REACT_11061Signalling by NGF
REACT_111102Signal Transduction
REACT_169165SMAD2/3 MH2 Domain Mutants in Cancer
REACT_169103SMAD2/3 Phosphorylation Motif Mutants in Cancer
REACT_169107SMAD4 MH2 Domain Mutants in Cancer
REACT_120726TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
REACT_169263TGFBR1 KD Mutants in Cancer
REACT_169445TGFBR1 LBD Mutants in Cancer
REACT_169440TGFBR2 Kinase Domain Mutants in Cancer
REACT_169192TGFBR2 MSI Frameshift Mutants in Cancer
REACT_264464VEGFA-VEGFR2 Pathway
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