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MGP000204

UniProt Annotations

Entry Information
Gene NameRho GTPase activating protein 6
Protein EntryRHG06_HUMAN
UniProt IDO43182
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=5; Name=3; IsoId=O43182-1; Sequence=Displayed; Name=1; IsoId=O43182-2; Sequence=VSP_001641, VSP_001642; Name=2; IsoId=O43182-3; Sequence=VSP_001638, VSP_001639, VSP_001640; Name=4; IsoId=O43182-4; Sequence=VSP_001637; Name=5; IsoId=O43182-5; Sequence=VSP_001637, VSP_001641, VSP_001642;
FunctionGTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Could regulate the interactions of signaling molecules with the actin cytoskeleton. Promotes continuous elongation of cytoplasmic processes during cell motility and simultaneous retraction of the cell body changing the cell morphology. {ECO:0000269|PubMed:10699171}.
MiscellaneousARHGAP6 gene undergoes X inactivation.
SimilarityContains 1 Rho-GAP domain. {ECO:0000255|PROSITE- ProRule:PRU00172}.
Subcellular LocationCytoplasm {ECO:0000269|PubMed:10699171}.
Tissue SpecificityHighly expressed in kidney, heart and skeletal muscle followed by retina, lymphoblast, placenta, lung, brain, pancreas and liver.
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