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MGP000206

Record overview

MGPD IDMGP000206
Gene ID397
SpeciesHomo sapiens (Human)
Gene NameRho GDP dissociation inhibitor (GDI) beta
Gene Symbol ARHGDIB
SynonymsD4; GDIA2; GDID4; LYGDI; Ly-GDI; RAP1GN1; RhoGDI2;
Alternate namesrho GDP-dissociation inhibitor 2; Rho GDI 2; rho-GDI beta;
Chromosome12
Map Location12p12.3
SummaryMembers of the Rho (or ARH) protein family (see MIM 165390) and other Ras-related small GTP-binding proteins (see MIM 179520) are involved in diverse cellular events, including cell signaling, proliferation, cytoskeletal organization, and secretion. The GTP-binding proteins are active only in the GTP-bound state. At least 3 classes of proteins tightly regulate cycling between the GTP-bound and GDP-bound states: GTPase-activating proteins (GAPs), guanine nucleotide-releasing factors (GRFs), and GDP-dissociation inhibitors (GDIs). The GDIs, including ARHGDIB, decrease the rate of GDP dissociation from Ras-like GTPases (summary by Scherle et al., 1993 [PubMed 8356058]).[supplied by OMIM, Dec 2010]
OrthologsView orthologs and multiple alignments for ARHGDIB

Proteins

rho GDP-dissociation inhibitor 2
Refseq ID:NP_001166
Protein GI:56676393
UniProt ID:P52566
mRNA ID:NM_001175
Length:201
RefSeq Status:
MTEKAPEPHVEEDDDDELDSKLNYKPPPQKSLKELQEMDKDDESLIKYKKTLLGDGPVVTDPKAPNVVVTRLTLVCESAPGPITMDLTGDLEALKKETIV
LKEGSEYRVKIHFKVNRDIVSGLKYVQHTYRTGVKVDKATFMVGSYGPRPEEYEFLTPVEEAPKGMLARGTYHNKSFFTDDDKQDHLSWEWNLSIKKEWT
E
 
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