MGP Database

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MGP000214

Ontology/Pathway Information

Entrez Gene ID409
Gene Namearrestin, beta 2
Gene Symbol ARRB2
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0016323 IEA:EnsemblCbasolateral plasma membrane
GO:0005905 IEA:UniProtKB-SubCellCcoated pit
GO:0005737 IDA:UniProtKBCcytoplasm
GO:0031410 IDA:UniProtKBCcytoplasmic vesicle
GO:0005829 TAS:ReactomeCcytosol
GO:0043197 IEA:EnsemblCdendritic spine
GO:0030139 IDA:UniProtKBCendocytic vesicle
GO:0005634 IDA:UniProtKBCnucleus
GO:0005886 IDA:UniProtKBCplasma membrane
GO:0014069 IEA:EnsemblCpostsynaptic density
GO:0045211 IEA:EnsemblCpostsynaptic membrane
GO:0031701 IPI:UniProtKBFangiotensin receptor binding
GO:0019899 IPI:UniProtKBFenzyme binding
GO:0001664 IPI:UniProtKBFG-protein coupled receptor binding
GO:0032947 IDA:BHF-UCLFprotein complex scaffold
GO:0005102 IPI:UniProtKBFreceptor binding
GO:0031625 IPI:UniProtKBFubiquitin protein ligase binding
GO:0007628 IEA:EnsemblPadult walking behavior
GO:0007596 TAS:ReactomePblood coagulation
GO:0007420 IEA:EnsemblPbrain development
GO:0060326 IMP:UniProtKBPcell chemotaxis
GO:0002032 IMP:UniProtKBPdesensitization of G-protein coupled receptor protein signaling pathway by arrestin
GO:0050965 IEA:EnsemblPdetection of temperature stimulus involved in sensory perception of pain
GO:0042699 IEA:EnsemblPfollicle-stimulating hormone signaling pathway
GO:0002031 IDA:UniProtKBPG-protein coupled receptor internalization
GO:0043154 IEA:EnsemblPnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0034260 IEA:EnsemblPnegative regulation of GTPase activity
GO:0032695 IEA:EnsemblPnegative regulation of interleukin-12 production
GO:0032691 IEA:EnsemblPnegative regulation of interleukin-1 beta production
GO:0032715 IEA:EnsemblPnegative regulation of interleukin-6 production
GO:0045953 IMP:UniProtKBPnegative regulation of natural killer cell mediated cytotoxicity
GO:0032088 IDA:UniProtKBPnegative regulation of NF-kappaB transcription factor activity
GO:0031397 IDA:UniProtKBPnegative regulation of protein ubiquitination
GO:0090201 IEA:EnsemblPnegative regulation of release of cytochrome c from mitochondria
GO:0034392 IEA:EnsemblPnegative regulation of smooth muscle cell apoptotic process
GO:0034122 IEA:EnsemblPnegative regulation of toll-like receptor signaling pathway
GO:0032720 IEA:EnsemblPnegative regulation of tumor necrosis factor production
GO:0007219 TAS:ReactomePNotch signaling pathway
GO:0030168 TAS:ReactomePplatelet activation
GO:0051928 IEA:EnsemblPpositive regulation of calcium ion transport
GO:2000573 IEA:EnsemblPpositive regulation of DNA biosynthetic process
GO:0070374 IDA:UniProtKBPpositive regulation of ERK1 and ERK2 cascade
GO:0033138 IEA:EnsemblPpositive regulation of peptidyl-serine phosphorylation
GO:0050731 IEA:EnsemblPpositive regulation of peptidyl-tyrosine phosphorylation
GO:0051897 IEA:EnsemblPpositive regulation of protein kinase B signaling
GO:0031398 IGI:BHF-UCLPpositive regulation of protein ubiquitination
GO:0002092 IMP:UniProtKBPpositive regulation of receptor internalization
GO:0032226 IEA:EnsemblPpositive regulation of synaptic transmission, dopaminergic
GO:0043161 IMP:UniProtKBPproteasome-mediated ubiquitin-dependent protein catabolic process
GO:0015031 IEA:UniProtKB-KWPprotein transport
GO:0016567 IMP:UniProtKBPprotein ubiquitination
GO:0031623 IDA:BHF-UCLPreceptor internalization
GO:0060765 IDA:BHF-UCLPregulation of androgen receptor signaling pathway
GO:0006366 IDA:UniProtKBPtranscription from RNA polymerase II promoter
GO:0007179 IDA:BHF-UCLPtransforming growth factor beta receptor signaling pathway
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_118614Activated NOTCH1 Transmits Signal to the Nucleus
REACT_267753Activation of SMO
REACT_264224beta-catenin independent WNT signaling
REACT_116125Disease
REACT_160099FBXW7 Mutants and NOTCH1 in Cancer
REACT_268718Hedgehog 'on' state
REACT_604Hemostasis
REACT_264199PCP/CE pathway
REACT_798Platelet activation, signaling and aggregation
REACT_264508Signaling by Hedgehog
REACT_299Signaling by NOTCH
REACT_118859Signaling by NOTCH1
REACT_160133Signaling by NOTCH1 HD Domain Mutants in Cancer
REACT_160248Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
REACT_160214Signaling by NOTCH1 in Cancer
REACT_160301Signaling by NOTCH1 PEST Domain Mutants in Cancer
REACT_160082Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
REACT_11045Signaling by Wnt
REACT_111102Signal Transduction
REACT_21384Thrombin signalling through proteinase activated receptors (PARs)
REACT_263890WNT5A-dependent internalization of FZD4
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