MGP Database

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MGP000217

UniProt Annotations

Entry Information
Gene Namesteroid sulfatase (microsomal), isozyme S
Protein EntrySTS_HUMAN
UniProt IDP08842
SpeciesHuman
Comments
Comment typeDescription
Catalytic Activity3-beta-hydroxyandrost-5-en-17-one 3-sulfate + H(2)O = 3-beta-hydroxyandrost-5-en-17-one + sulfate.
CofactorName=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000269|PubMed:12657638}; Note=Binds 1 Ca(2+) ion per subunit. {ECO:0000269|PubMed:12657638};
DiseaseIchthyosis, X-linked (IXL) [MIM:308100]: A keratinization disorder manifesting with mild erythroderma and generalized exfoliation of the skin within a few weeks after birth. Affected boys later develop large, polygonal, dark brown scales, especially on the neck, extremities, trunk, and buttocks. {ECO:0000269|PubMed:10679952, ECO:0000269|PubMed:10844566, ECO:0000269|PubMed:1539590, ECO:0000269|PubMed:9252398}. Note=The disease is caused by mutations affecting the gene represented in this entry.
FunctionConversion of sulfated steroid precursors to estrogens during pregnancy.
PtmThe conversion to 3-oxoalanine (also known as C- formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. {ECO:0000269|PubMed:12657638}.
SimilarityBelongs to the sulfatase family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane; Multi-pass membrane protein.
SubunitHomodimer. {ECO:0000269|PubMed:12657638}.
Web ResourceName=Wikipedia; Note=Steroid sulfatase entry; URL="http://en.wikipedia.org/wiki/Steroid_sulfatase";
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