MGP Database

MGP000227

Ontology/Pathway Information

Entrez Gene ID	445
Gene Name	argininosuccinate synthase 1
Gene Symbol	ASS1
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0070852	IEA:Ensembl	C	cell body fiber
GO:0005737	IBA:GO_Central	C	cytoplasm
GO:0005829	TAS:Reactome	C	cytosol
GO:0005783	IEA:Ensembl	C	endoplasmic reticulum
GO:0070062	IDA:UniProtKB	C	extracellular vesicular exosome
GO:0005764	IEA:Ensembl	C	lysosome
GO:0005741	IEA:Ensembl	C	mitochondrial outer membrane
GO:0005634	IEA:Ensembl	C	nucleus
GO:0043204	IEA:Ensembl	C	perikaryon
GO:0016597	IMP:BHF-UCL	F	amino acid binding
GO:0004055	IMP:BHF-UCL	F	argininosuccinate synthase activity
GO:0005524	IEA:UniProtKB-KW	F	ATP binding
GO:0044822	IDA:UniProtKB	F	poly(A) RNA binding
GO:0015643	IEA:Ensembl	F	toxic substance binding
GO:0006953	IEA:Ensembl	P	acute-phase response
GO:0007568	IEA:Ensembl	P	aging
GO:0006526	IBA:GO_Central	P	arginine biosynthetic process
GO:0000053	IMP:BHF-UCL	P	argininosuccinate metabolic process
GO:0006531	IMP:BHF-UCL	P	aspartate metabolic process
GO:0034641	TAS:Reactome	P	cellular nitrogen compound metabolic process
GO:0071418	IEA:Ensembl	P	cellular response to amine stimulus
GO:0071230	IEA:Ensembl	P	cellular response to amino acid stimulus
GO:0071242	IEA:Ensembl	P	cellular response to ammonium ion
GO:0071320	IEA:Ensembl	P	cellular response to cAMP
GO:0071549	IEA:Ensembl	P	cellular response to dexamethasone stimulus
GO:0071377	IEA:Ensembl	P	cellular response to glucagon stimulus
GO:0071346	IEA:Ensembl	P	cellular response to interferon-gamma
GO:0071499	IMP:BHF-UCL	P	cellular response to laminar fluid shear stress
GO:0071222	IEA:Ensembl	P	cellular response to lipopolysaccharide
GO:0071400	IEA:Ensembl	P	cellular response to oleic acid
GO:0071356	IEA:Ensembl	P	cellular response to tumor necrosis factor
GO:0000052	IMP:BHF-UCL	P	citrulline metabolic process
GO:0060539	IEA:Ensembl	P	diaphragm development
GO:0001822	IEA:Ensembl	P	kidney development
GO:0001889	IEA:Ensembl	P	liver development
GO:0007494	IEA:Ensembl	P	midgut development
GO:1903038	IMP:BHF-UCL	P	negative regulation of leukocyte cell-cell adhesion
GO:0045429	IMP:BHF-UCL	P	positive regulation of nitric oxide biosynthetic process
GO:0042493	IEA:Ensembl	P	response to drug
GO:0032355	IEA:Ensembl	P	response to estradiol
GO:0060416	IEA:Ensembl	P	response to growth hormone
GO:0010046	IEA:Ensembl	P	response to mycotoxin
GO:0007584	IEA:Ensembl	P	response to nutrient
GO:0010043	IEA:Ensembl	P	response to zinc ion
GO:0044281	TAS:Reactome	P	small molecule metabolic process
GO:0000050	IMP:BHF-UCL	P	urea cycle

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_111217	Metabolism
REACT_13	Metabolism of amino acids and derivatives
REACT_847	Urea cycle

SMP Pathway Links

SMP ID	Description
SMP00020	Arginine and Proline Metabolism
SMP00362	Arginine: Glycine Amidinotransferase Deficiency (AGAT Deficiency)
SMP00357	Argininemia
SMP00003	Argininosuccinic Aciduria
SMP00067	Aspartate Metabolism
SMP00175	Canavan Disease
SMP00002	Carbamoyl Phosphate Synthetase Deficiency
SMP00001	Citrullinemia Type I
SMP00504	Creatine deficiency, guanidinoacetate methyltransferase deficiency
SMP00188	Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency)
SMP00506	Hyperornithinemia-hyperammonemia-homocitrullinuria [HHH-syndrome]
SMP00505	Hyperornithinemia with gyrate atrophy (HOGA)
SMP00361	Hyperprolinemia Type I
SMP00360	Hyperprolinemia Type II
SMP00192	Hypoacetylaspartia
SMP00507	L-arginine:glycine amidinotransferase deficiency
SMP00363	Ornithine Aminotransferase Deficiency (OAT Deficiency)
SMP00205	Ornithine Transcarbamylase Deficiency (OTC Deficiency)
SMP00207	Prolidase Deficiency (PD)
SMP00208	Prolinemia Type II
SMP00059	Urea Cycle