MGP Database

MGP000232

Ontology/Pathway Information

Entrez Gene ID	471
Gene Name	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
Gene Symbol	ATIC
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005829	TAS:Reactome	C	cytosol
GO:0070062	IDA:UniProtKB	C	extracellular vesicular exosome
GO:0016020	IDA:UniProtKB	C	membrane
GO:0005739	IEA:Ensembl	C	mitochondrion
GO:0003937	TAS:Reactome	F	IMP cyclohydrolase activity
GO:0004643	TAS:Reactome	F	phosphoribosylaminoimidazolecarboxamide formyltransferase activity
GO:0042803	IPI:UniProtKB	F	protein homodimerization activity
GO:0003360	IEA:Ensembl	P	brainstem development
GO:0021549	IEA:Ensembl	P	cerebellum development
GO:0021987	IEA:Ensembl	P	cerebral cortex development
GO:0006189	IEA:UniProtKB-UniPathway	P	'de novo' IMP biosynthetic process
GO:0046452	IEA:Ensembl	P	dihydrofolate metabolic process
GO:0006139	TAS:ProtInc	P	nucleobase-containing compound metabolic process
GO:0055086	TAS:Reactome	P	nucleobase-containing small molecule metabolic process
GO:0009116	IEA:Ensembl	P	nucleoside metabolic process
GO:0031100	IEA:Ensembl	P	organ regeneration
GO:0006144	TAS:Reactome	P	purine nucleobase metabolic process
GO:0009168	TAS:Reactome	P	purine ribonucleoside monophosphate biosynthetic process
GO:0010035	IEA:Ensembl	P	response to inorganic substance
GO:0044281	TAS:Reactome	P	small molecule metabolic process
GO:0046654	IEA:Ensembl	P	tetrahydrofolate biosynthetic process

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_111217	Metabolism
REACT_1698	Metabolism of nucleotides
REACT_522	Purine metabolism
REACT_1776	Purine ribonucleoside monophosphate biosynthesis

SMP Pathway Links

SMP ID	Description
SMP00535	Adenine phosphoribosyltransferase deficiency (APRT)
SMP00144	Adenosine Deaminase Deficiency
SMP00167	Adenylosuccinate Lyase Deficiency
SMP00168	AICA-Ribosiduria
SMP00427	Azathioprine Action Pathway
SMP00365	Gout or Kelley-Seegmiller Syndrome
SMP00364	Lesch-Nyhan Syndrome (LNS)
SMP00428	Mercaptopurine Action Pathway
SMP00536	Mitochondrial DNA depletion syndrome
SMP00203	Molybdenum Cofactor Deficiency
SMP00537	Myoadenylate deaminase deficiency
SMP00050	Purine Metabolism
SMP00210	Purine Nucleoside Phosphorylase Deficiency
SMP00430	Thioguanine Action Pathway
SMP00220	Xanthine Dehydrogenase Deficiency (Xanthinuria)
SMP00512	Xanthinuria type I
SMP00513	Xanthinuria type II