MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP000235

UniProt Annotations

Entry Information
Gene NameATPase, Na+/K+ transporting, alpha 1 polypeptide
Protein EntryAT1A1_HUMAN
UniProt IDP05023
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=4; Name=1; Synonyms=Long; IsoId=P05023-1; Sequence=Displayed; Name=2; Synonyms=Short; IsoId=P05023-2; Sequence=VSP_000415, VSP_000416; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=3; IsoId=P05023-3; Sequence=VSP_044242; Name=4; IsoId=P05023-4; Sequence=VSP_047309;
Catalytic ActivityATP + H(2)O + Na(+)(In) + K(+)(Out) = ADP + phosphate + Na(+)(Out) + K(+)(In).
FunctionThis is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.
InteractionP13693:TPT1; NbExp=5; IntAct=EBI-358778, EBI-1783169;
PtmPhosphorylation on Tyr-10 modulates pumping activity. Phosphorylation of Ser-943 by PKA modulates the response of ATP1A1 to PKC. Dephosphorylation by protein phosphatase 2A (PP2A) following increases in intracellular sodium, leading to increase catalytic activity (By similarity). {ECO:0000250}.
SimilarityBelongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily. {ECO:0000305}.
Subcellular LocationCell membrane; Multi-pass membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
SubunitInteracts with SIK1 (By similarity). Composed of three subunits: alpha (catalytic), beta and gamma. Binds the HLA class II histocompatibility antigen, DR1. Interacts with SLC35G1 and STIM1. {ECO:0000250, ECO:0000269|PubMed:1380674, ECO:0000269|PubMed:22084111}.
  logo