MGP Database

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MGP000236

Ontology/Pathway Information

Entrez Gene ID477
Gene NameATPase, Na+/K+ transporting, alpha 2 polypeptide
Gene Symbol ATP1A2
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005901 IEA:EnsemblCcaveola
GO:0005737 IDA:UniProtKBCcytoplasm
GO:0043197 IEA:EnsemblCdendritic spine
GO:0005768 IEA:EnsemblCendosome
GO:0005886 IDA:UniProtKBCplasma membrane
GO:0005890 IC:UniProtKBCsodium:potassium-exchanging ATPase complex
GO:0045202 IEA:EnsemblCsynapse
GO:0030315 IEA:EnsemblCT-tubule
GO:0031982 IDA:UniProtKBCvesicle
GO:0005524 IEA:UniProtKB-KWFATP binding
GO:0051087 IPI:BHF-UCLFchaperone binding
GO:0046872 IEA:UniProtKB-KWFmetal ion binding
GO:0005391 IMP:UniProtKBFsodium:potassium-exchanging ATPase activity
GO:1990239 IDA:BHF-UCLFsteroid hormone binding
GO:0008344 IEA:EnsemblPadult locomotory behavior
GO:0006754 IEA:InterProPATP biosynthetic process
GO:0015991 IEA:EnsemblPATP hydrolysis coupled proton transport
GO:0060048 TAS:BHF-UCLPcardiac muscle contraction
GO:0086064 TAS:BHF-UCLPcell communication by electrical coupling involved in cardiac conduction
GO:0030007 IDA:BHF-UCLPcellular potassium ion homeostasis
GO:0071260 IEA:EnsemblPcellular response to mechanical stimulus
GO:0071383 IDA:BHF-UCLPcellular response to steroid hormone stimulus
GO:0006883 IDA:BHF-UCLPcellular sodium ion homeostasis
GO:0034220 TAS:ReactomePion transmembrane transport
GO:0040011 IEA:EnsemblPlocomotion
GO:0086012 TAS:BHF-UCLPmembrane depolarization during cardiac muscle cell action potential
GO:0051481 IEA:EnsemblPnegative regulation of cytosolic calcium ion concentration
GO:0045822 IEA:EnsemblPnegative regulation of heart contraction
GO:0045988 IEA:EnsemblPnegative regulation of striated muscle contraction
GO:0001504 IEA:EnsemblPneurotransmitter uptake
GO:0010107 IDA:BHF-UCLPpotassium ion import
GO:0006813 NAS:UniProtKBPpotassium ion transport
GO:0008217 IEA:EnsemblPregulation of blood pressure
GO:0086004 IEA:EnsemblPregulation of cardiac muscle cell contraction
GO:0010881 TAS:BHF-UCLPregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO:0002087 IEA:EnsemblPregulation of respiratory gaseous exchange by neurological system process
GO:0006940 IEA:EnsemblPregulation of smooth muscle contraction
GO:0006942 NAS:UniProtKBPregulation of striated muscle contraction
GO:0002026 IEA:EnsemblPregulation of the force of heart contraction
GO:0019229 IEA:EnsemblPregulation of vasoconstriction
GO:0055119 TAS:BHF-UCLPrelaxation of cardiac muscle
GO:1903416 IC:BHF-UCLPresponse to glycoside
GO:0035094 IEA:EnsemblPresponse to nicotine
GO:0036376 IDA:BHF-UCLPsodium ion export from cell
GO:0006814 NAS:UniProtKBPsodium ion transport
GO:0055085 TAS:ReactomePtransmembrane transport
GO:0008542 IEA:EnsemblPvisual learning
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_25300Ion channel transport
REACT_25149Ion transport by P-type ATPases
REACT_15518Transmembrane transport of small molecules
SMP Pathway Links
SMP IDDescription
SMP006793-Methylthiofentanyl Action Pathway
SMP00296Acebutolol Action Pathway
SMP00413Alfentanil Action Pathway
SMP00297Alprenolol Action Pathway
SMP00685Alvimopan Action Pathway
SMP00133Amiloride Action Pathway
SMP00665Amiodarone Action Pathway
SMP00376Amlodipine Action Pathway
SMP00674Anileridine Action Pathway
SMP00664Arbutamine Action Pathway
SMP00298Atenolol Action Pathway
SMP00090Bendroflumethiazide Action Pathway
SMP00392Benzocaine Action Pathway
SMP00299Betaxolol Action Pathway
SMP00668Bevantolol Action Pathway
SMP00300Bisoprolol Action Pathway
SMP00583Blue diaper syndrome
SMP00657Bopindolol Action Pathway
SMP00088Bumetanide Action Pathway
SMP00393Bupivacaine Action Pathway
SMP00670Bupranolol Action Pathway
SMP00684Buprenorphine Action Pathway
SMP00414Carfentanil Action Pathway
SMP00658Carteolol Action Pathway
SMP00367Carvedilol Action Pathway
SMP00394Chloroprocaine Action Pathway
SMP00078Chlorothiazide Action Pathway
SMP00122Chlorthalidone Action Pathway
SMP00424Citalopram Action Pathway
SMP00395Cocaine Action Pathway
SMP00405Codeine Action Pathway
SMP00103Cyclothiazide Action Pathway
SMP00723Cystinuria
SMP00423Desipramine Action Pathway
SMP00676Dezocine Action Pathway
SMP00396Dibucaine Action Pathway
SMP00689Dihydromorphine Action Pathway
SMP00359Diltiazem Action Pathway
SMP00680Dimethylthiambutene Action Pathway
SMP00675Diphenoxylate Action Pathway
SMP00325Disopyramide Action Pathway
SMP00662Dobutamine Action Pathway
SMP00661Epinephrine Action Pathway
SMP00135Eplerenone Action Pathway
SMP00425Escitalopram Action Pathway
SMP00301Esmolol Action Pathway
SMP00097Ethacrynic Acid Action Pathway
SMP00681Ethylmorphine Action Pathway
SMP00377Felodipine Action Pathway
SMP00415Fentanyl Action Pathway
SMP00331Flecainide Action Pathway
SMP00426Fluoxetine Action Pathway
SMP00326Fosphenytoin (Antiarrhythmic) Action Pathway
SMP00115Furosemide Action Pathway
SMP00245Glucose Transporter Defect (SGLT2)
SMP00189Hartnup Disorder
SMP00407Heroin Action Pathway
SMP00100Hydrochlorothiazide Action Pathway
SMP00411Hydrocodone Action Pathway
SMP00108Hydroflumethiazide Action Pathway
SMP00410Hydromorphone Action Pathway
SMP00332Ibutilide Action Pathway
SMP00193Iminoglycinuria
SMP00584Iminoglycinuria
SMP00422Imipramine Action Pathway
SMP00110Indapamide Action Pathway
SMP00663Isoprenaline Action Pathway
SMP00378Isradipine Action Pathway
SMP00690Ketobemidone Action Pathway
SMP00483Kidney Function
SMP00368Labetalol Action Pathway
SMP00457Lactose Degradation
SMP00458Lactose Intolerance
SMP00683Levallorphan Action Pathway
SMP00666Levobunolol Action Pathway
SMP00397Levobupivacaine Action Pathway
SMP00677Levomethadyl Acetate Action Action Pathway
SMP00673Levorphanol Action Pathway
SMP00328Lidocaine (Antiarrhythmic) Action Pathway
SMP00398Lidocaine (Local Anaesthetic) Action Pathway
SMP00197Lysinuric Protein Intolerance
SMP00585Lysinuric protein intolerance (LPI)
SMP00399Mepivacaine Action Pathway
SMP00408Methadone Action Pathway
SMP00678Methadyl Acetate Action Pathway
SMP00081Methyclothiazide Action Pathway
SMP00667Metipranolol Action Pathway
SMP00105Metolazone Action Pathway
SMP00302Metoprolol Action Pathway
SMP00329Mexiletine Action Pathway
SMP00406Morphine Action Pathway
SMP00588Muscle/Heart Contraction
SMP00303Nadolol Action Pathway
SMP00691Nalbuphine Action Pathway
SMP00688Naloxone Action Pathway
SMP00687Naltrexone Action Pathway
SMP00366Nebivolol Action Pathway
SMP00431Nicotine Action Pathway
SMP00379Nifedipine Action Pathway
SMP00380Nimodipine Action Pathway
SMP00381Nisoldipine Action Pathway
SMP00382Nitrendipine Action Pathway
SMP00304Oxprenolol Action Pathway
SMP00400Oxybuprocaine Action Pathway
SMP00409Oxycodone Action Pathway
SMP00412Oxymorphone Action Pathway
SMP00305Penbutolol Action Pathway
SMP00686Pentazocine Action Pathway
SMP00327Phenytoin (Antiarrhythmic) Action Pathway
SMP00306Pindolol Action Pathway
SMP00080Polythiazide Action Pathway
SMP00669Practolol Action Pathway
SMP00401Prilocaine Action Pathway
SMP00324Procainamide (Antiarrhythmic) Action Pathway
SMP00402Procaine Action Pathway
SMP00403Proparacaine Action Pathway
SMP00672Propoxyphene Action Pathway
SMP00307Propranolol Action Pathway
SMP00091Quinethazone Action Pathway
SMP00323Quinidine Action Pathway
SMP00416Remifentanil Action Pathway
SMP00184Renal Glucosuria
SMP00404Ropivacaine Action Pathway
SMP00660Sotalol Action Pathway
SMP00134Spironolactone Action Pathway
SMP00417Sufentanil Action Pathway
SMP00659Timolol Action Pathway
SMP00330Tocainide Action Pathway
SMP00118Torsemide Action Pathway
SMP00671Tramadol Action Action Pathway
SMP00467Trehalose Degradation
SMP00132Triamterene Action Pathway
SMP00121Trichlormethiazide Action Pathway
SMP00375Verapamil Action Pathway
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