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MGP000241

Record overview

MGPD IDMGP000241
Gene ID482
SpeciesHomo sapiens (Human)
Gene NameATPase, Na+/K+ transporting, beta 2 polypeptide
Gene Symbol ATP1B2
SynonymsAMOG;
Alternate namessodium/potassium-transporting ATPase subunit beta-2; adhesion molecule in glia; adhesion molecule on glia; sodium pump subunit beta-2; Na, K-ATPase beta-2 polypeptide; sodium/potassium-dependent ATPase beta-2 subunit; sodium/potassium-dependent ATPase subunit beta-2; sodium/potassium-transporting ATPase beta-2 chain; sodium-potassium ATPase subunit beta 2 (non-catalytic);
Chromosome17
Map Location17p13.1
SummaryThe protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 2 subunit. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014]
OrthologsView orthologs and multiple alignments for ATP1B2

Proteins

sodium/potassium-transporting ATPase subunit beta-2 isoform 1
Refseq ID:NP_001669
Protein GI:49574491
UniProt ID:P14415
mRNA ID:NM_001678
Length:290
RefSeq Status:
MVIQKEKKSCGQVVEEWKEFVWNPRTHQFMGRTGTSWAFILLFYLVFYGFLTAMFTLTMWVMLQTVSDHTPKYQDRLATPGLMIRPKTENLDVIVNVSDT
ESWDQHVQKLNKFLEPYNDSIQAQKNDVCRPGRYYEQPDNGVLNYPKRACQFNRTQLGNCSGIGDSTHYGYSTGQPCVFIKMNRVINFYAGANQSMNVTC
AGKRDEDAENLGNFVMFPANGNIDLMYFPYYGKKFHVNYTQPLVAVKFLNVTPNVEVNVECRINAANIATDDERDKFAGRVAFKLRINKT
 
sodium/potassium-transporting ATPase subunit beta-2 isoform 2
Refseq ID:NP_001290192
Protein GI:737676209
UniProt ID:
mRNA ID:NM_001303263
Length:208
RefSeq Status:
MIRPKTENLDVIVNVSDTESWDQHVQKLNKFLEPYNDSIQAQKNDVCRPGRYYEQPDNGVLNYPKRACQFNRTQLGNCSGIGDSTHYGYSTGQPCVFIKM
NRVINFYAGANQSMNVTCAGKRDEDAENLGNFVMFPANGNIDLMYFPYYGKKFHVNYTQPLVAVKFLNVTPNVEVNVECRINAANIATDDERDKFAGRVA
FKLRINKT
 
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