MGP Database

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MGP000245

Ontology/Pathway Information

Entrez Gene ID488
Gene NameATPase, Ca++ transporting, cardiac muscle, slow twitch 2
Gene Symbol ATP2A2
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0090534 IDA:BHF-UCLCcalcium ion-transporting ATPase complex
GO:0005783 IDA:UniProtKBCendoplasmic reticulum
GO:0005789 IDA:UniProtKBCendoplasmic reticulum membrane
GO:0005887 TAS:ProtIncCintegral component of plasma membrane
GO:0014801 IDA:BHF-UCLClongitudinal sarcoplasmic reticulum
GO:0016020 IDA:MGICmembrane
GO:0031095 TAS:ReactomeCplatelet dense tubular network membrane
GO:0016529 IDA:BHF-UCLCsarcoplasmic reticulum
GO:0033017 TAS:BHF-UCLCsarcoplasmic reticulum membrane
GO:0005524 IEA:UniProtKB-KWFATP binding
GO:0005509 IDA:BHF-UCLFcalcium ion binding
GO:0005388 IDA:BHF-UCLFcalcium-transporting ATPase activity
GO:0086039 ISS:BHF-UCLFcalcium-transporting ATPase activity involved in regulation of cardiac muscle cell membrane potential
GO:0019899 IPI:BHF-UCLFenzyme binding
GO:0046872 IEA:UniProtKB-KWFmetal ion binding
GO:0008022 IPI:UniProtKBFprotein C-terminus binding
GO:0044548 IPI:UniProtKBFS100 protein binding
GO:0007596 TAS:ReactomePblood coagulation
GO:1990036 ISS:BHF-UCLPcalcium ion import into sarcoplasmic reticulum
GO:0070588 IDA:BHF-UCLPcalcium ion transmembrane transport
GO:1903515 IDA:BHF-UCLPcalcium ion transport from cytosol to endoplasmic reticulum
GO:0007155 TAS:ProtIncPcell adhesion
GO:0006874 IDA:BHF-UCLPcellular calcium ion homeostasis
GO:0032469 IDA:BHF-UCLPendoplasmic reticulum calcium ion homeostasis
GO:0008544 TAS:ProtIncPepidermis development
GO:0006984 IEA:EnsemblPER-nucleus signaling pathway
GO:0034220 TAS:ReactomePion transmembrane transport
GO:0045822 IEA:EnsemblPnegative regulation of heart contraction
GO:0032470 IDA:BHF-UCLPpositive regulation of endoplasmic reticulum calcium ion concentration
GO:0010460 TAS:BHF-UCLPpositive regulation of heart rate
GO:0098909 ISS:BHF-UCLPregulation of cardiac muscle cell action potential involved in regulation of contraction
GO:0086036 ISS:BHF-UCLPregulation of cardiac muscle cell membrane potential
GO:0010882 IDA:BHF-UCLPregulation of cardiac muscle contraction by calcium ion signaling
GO:0002026 IEA:EnsemblPregulation of the force of heart contraction
GO:0055119 IDA:BHF-UCLPrelaxation of cardiac muscle
GO:0070296 TAS:BHF-UCLPsarcoplasmic reticulum calcium ion transport
GO:0055085 TAS:ReactomePtransmembrane transport
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_604Hemostasis
REACT_25300Ion channel transport
REACT_25149Ion transport by P-type ATPases
REACT_23905Platelet calcium homeostasis
REACT_23876Platelet homeostasis
REACT_118744Pre-NOTCH Expression and Processing
REACT_118798Pre-NOTCH Processing in Golgi
REACT_23765Reduction of cytosolic Ca++ levels
REACT_299Signaling by NOTCH
REACT_111102Signal Transduction
REACT_15518Transmembrane transport of small molecules
SMP Pathway Links
SMP IDDescription
SMP00296Acebutolol Action Pathway
SMP00297Alprenolol Action Pathway
SMP00665Amiodarone Action Pathway
SMP00376Amlodipine Action Pathway
SMP00664Arbutamine Action Pathway
SMP00298Atenolol Action Pathway
SMP00299Betaxolol Action Pathway
SMP00668Bevantolol Action Pathway
SMP00300Bisoprolol Action Pathway
SMP00657Bopindolol Action Pathway
SMP00670Bupranolol Action Pathway
SMP00658Carteolol Action Pathway
SMP00367Carvedilol Action Pathway
SMP00359Diltiazem Action Pathway
SMP00325Disopyramide Action Pathway
SMP00662Dobutamine Action Pathway
SMP00661Epinephrine Action Pathway
SMP00301Esmolol Action Pathway
SMP00377Felodipine Action Pathway
SMP00331Flecainide Action Pathway
SMP00326Fosphenytoin (Antiarrhythmic) Action Pathway
SMP00332Ibutilide Action Pathway
SMP00663Isoprenaline Action Pathway
SMP00378Isradipine Action Pathway
SMP00368Labetalol Action Pathway
SMP00666Levobunolol Action Pathway
SMP00328Lidocaine (Antiarrhythmic) Action Pathway
SMP00667Metipranolol Action Pathway
SMP00302Metoprolol Action Pathway
SMP00329Mexiletine Action Pathway
SMP00588Muscle/Heart Contraction
SMP00303Nadolol Action Pathway
SMP00366Nebivolol Action Pathway
SMP00379Nifedipine Action Pathway
SMP00380Nimodipine Action Pathway
SMP00381Nisoldipine Action Pathway
SMP00382Nitrendipine Action Pathway
SMP00304Oxprenolol Action Pathway
SMP00305Penbutolol Action Pathway
SMP00327Phenytoin (Antiarrhythmic) Action Pathway
SMP00306Pindolol Action Pathway
SMP00669Practolol Action Pathway
SMP00324Procainamide (Antiarrhythmic) Action Pathway
SMP00307Propranolol Action Pathway
SMP00323Quinidine Action Pathway
SMP00660Sotalol Action Pathway
SMP00659Timolol Action Pathway
SMP00330Tocainide Action Pathway
SMP00375Verapamil Action Pathway
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