MGP Database

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MGP000246

UniProt Annotations

Entry Information
Gene NameATPase, Ca++ transporting, ubiquitous
Protein EntryAT2A3_HUMAN
UniProt IDQ93084
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=7; Comment=The same names have been attributed to different isoforms.; Name=SERCA3B; IsoId=Q93084-1; Sequence=Displayed; Name=SERCA3A; Synonyms=HuS3-II; IsoId=Q93084-2; Sequence=VSP_000364; Name=SERCA3C; Synonyms=HuS3-IV; IsoId=Q93084-3; Sequence=VSP_000366; Name=SERCA3G; Synonyms=HuS3-I; IsoId=Q93084-4; Sequence=VSP_000365; Name=SERCA3E; IsoId=Q93084-5; Sequence=VSP_000367; Name=SERCA3D; IsoId=Q93084-6; Sequence=VSP_000368; Name=SERCA3F; IsoId=Q93084-7; Sequence=VSP_042296;
Catalytic ActivityATP + H(2)O + Ca(2+)(Side 1) = ADP + phosphate + Ca(2+)(Side 2).
FunctionThis magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports calcium ions from the cytosol into the sarcoplasmic/endoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction. {ECO:0000269|PubMed:11956212, ECO:0000269|PubMed:15028735}.
SimilarityBelongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily. {ECO:0000305}.
Subcellular LocationNucleus membrane {ECO:0000269|PubMed:15028735}; Multi-pass membrane protein {ECO:0000269|PubMed:15028735}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:15028735}; Multi-pass membrane protein {ECO:0000269|PubMed:15028735}. Sarcoplasmic reticulum membrane {ECO:0000269|PubMed:15028735}; Multi-pass membrane protein {ECO:0000269|PubMed:15028735}.
Tissue SpecificityFound in most tissues. Most abundant in thymus, trachea, salivary gland, spleen, bone marrow, lymph node, peripheral leukocytes, pancreas and colon. Also detected in fetal tissues. Expressed in cell lineages of hematopoietic, epithelial, or embryonic origin and also expressed in several cancer cell lines. {ECO:0000269|PubMed:11956212, ECO:0000269|PubMed:15028735}.
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