MGP Database

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MGP000247

UniProt Annotations

Entry Information
Gene NameATPase, Ca++ transporting, plasma membrane 1
Protein EntryAT2B1_HUMAN
UniProt IDP20020
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=6; Name=D; Synonyms=CIV; IsoId=P20020-1; Sequence=Displayed; Name=A; Synonyms=CII; IsoId=P20020-2; Sequence=VSP_000375; Name=B; Synonyms=CI; IsoId=P20020-3; Sequence=VSP_000373; Name=C; Synonyms=CIII; IsoId=P20020-4; Sequence=VSP_000374; Name=E; Synonyms=CV; IsoId=P20020-5; Sequence=VSP_000376; Name=K; IsoId=P20020-6; Sequence=VSP_000372, VSP_000373;
Catalytic ActivityATP + H(2)O + Ca(2+)(Side 1) = ADP + phosphate + Ca(2+)(Side 2).
DomainThe calmodulin-binding subdomain B is different in the different splice variants and shows pH dependent calmodulin binding properties in isoforms A, C, D and E.
FunctionThis magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell.
SimilarityBelongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily. {ECO:0000305}.
Subcellular LocationCell membrane; Multi-pass membrane protein.
SubunitInteracts with PDZD11. Interacts with SLC35G1 and STIM1. {ECO:0000269|PubMed:12763866, ECO:0000269|PubMed:22084111}.
Tissue SpecificityIsoform B is ubiquitously expressed. Isoform C is found in brain cortex, skeletal muscle and heart muscle. Isoform D has only been found in fetal skeletal muscle. Isoform K has been found in small intestine and liver.
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