MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP000248

UniProt Annotations

Entry Information
Gene NameATPase, Ca++ transporting, plasma membrane 2
Protein EntryAT2B2_HUMAN
UniProt IDQ01814
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=8; Comment=There is a combination of two alternative spliced domains at N-terminal site A (Z, X, Y and W) and at C-terminal site C (A and B). So far the splice sites have only been studied independently. Experimental confirmation may be lacking for some isoforms.; Name=WB; Synonyms=AIIICI; IsoId=Q01814-1; Sequence=Displayed; Name=WA; Synonyms=AIIICII; IsoId=Q01814-2; Sequence=VSP_000386; Note=Contains a phosphoserine at position 1177.; Name=YA; Synonyms=AIICII; IsoId=Q01814-3; Sequence=VSP_000385, VSP_000386; Note=Contains a phosphoserine at position 1163.; Name=ZA; Synonyms=AICII; IsoId=Q01814-4; Sequence=VSP_000384, VSP_000386; Note=Contains a phosphoserine at position 1132.; Name=YB; Synonyms=AIICI; IsoId=Q01814-5; Sequence=VSP_000385; Name=ZB; Synonyms=AICI; IsoId=Q01814-6; Sequence=VSP_000384; Name=XA; IsoId=Q01814-7; Sequence=VSP_040837, VSP_000386; Note=Contains a phosphoserine at position 1146.; Name=XB; IsoId=Q01814-8; Sequence=VSP_040837;
Catalytic ActivityATP + H(2)O + Ca(2+)(Side 1) = ADP + phosphate + Ca(2+)(Side 2).
FunctionThis magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell.
InteractionP01258:CALCA; NbExp=2; IntAct=EBI-1174243, EBI-1018474; Q63622:Dlg2 (xeno); NbExp=2; IntAct=EBI-1174262, EBI-396947; Q8SQG9:SLC9A3R2 (xeno); NbExp=3; IntAct=EBI-1174262, EBI-1174758;
SimilarityBelongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily. {ECO:0000305}.
Subcellular LocationCell junction, synapse {ECO:0000250|UniProtKB:Q9R0K7}. Cell membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
SubunitInteracts with PDZD11. {ECO:0000269|PubMed:12763866}.
Tissue SpecificityMainly expressed in brain cortex. Found in low levels in skeletal muscle, heart muscle, stomach, liver, kidney and lung. Isoforms containing segment B are found in brain cortex and at low levels in other tissues. Isoforms containing segments X and W are found at low levels in all tissues. Isoforms containing segment A and segment Z are found at low levels in skeletal muscle and heart muscle.
  logo