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MGP000250

UniProt Annotations

Entry Information
Gene NameATPase, Ca++ transporting, plasma membrane 4
Protein EntryAT2B4_HUMAN
UniProt IDP23634
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=8; Comment=There is a combination of two alternatively spliced domains at N-terminal site A (X and Z) and at C-terminal site B/C (A, B, D and K). The splice sites have mostly been studied independently. Full isoforms so far detected are isoform XA and isoform XB. Experimental confirmation may be lacking for some isoforms.; Name=XD; Synonyms=AIICIV; IsoId=P23634-1; Sequence=Displayed; Name=XA; Synonyms=AIICII; IsoId=P23634-2; Sequence=VSP_000405; Name=ZA; Synonyms=AICII; IsoId=P23634-3; Sequence=VSP_000402, VSP_000405; Name=XK; Synonyms=XG; IsoId=P23634-4; Sequence=VSP_000403, VSP_000405; Name=ZK; Synonyms=ZG; IsoId=P23634-5; Sequence=VSP_000402, VSP_000403, VSP_000405; Name=XB; Synonyms=AIICI; IsoId=P23634-6; Sequence=VSP_000404; Name=ZB; Synonyms=AICI; IsoId=P23634-7; Sequence=VSP_000402, VSP_000404; Name=ZD; Synonyms=AICIV; IsoId=P23634-8; Sequence=VSP_000402;
Catalytic ActivityATP + H(2)O + Ca(2+)(Side 1) = ADP + phosphate + Ca(2+)(Side 2).
FunctionThis magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell.
InteractionP01258:CALCA; NbExp=2; IntAct=EBI-1174388, EBI-1018474; Q63622:Dlg2 (xeno); NbExp=2; IntAct=EBI-1174437, EBI-396947; Q62936:Dlg3 (xeno); NbExp=2; IntAct=EBI-1174437, EBI-349596;
SimilarityBelongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily. {ECO:0000305}.
Subcellular LocationCell membrane; Multi-pass membrane protein.
SubunitInteracts with PDZD11. Interacts with SLC35G1 and STIM1. {ECO:0000269|PubMed:10493800, ECO:0000269|PubMed:12763866, ECO:0000269|PubMed:22084111}.
Tissue SpecificityIsoform XB is the most abundant isoform and is expressed ubiquitously. Isoforms containing segment Z have only been detected in heart, while isoforms containing segment a have been found in heart, stomach and brain cortex.
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